8DVM

Crystal structure of LRP6 E3E4 in complex with disulfide constrained peptide E3.6

Summary for 8DVM

• Entry DOI: 10.2210/pdb8dvm/pdb
• Descriptor: Low-density lipoprotein receptor-related protein 6, E3.6 Disulfide constrained peptide, alpha-L-fucopyranose-(1-3)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• Functional Keywords: lrp6, e3e4, wnt signaling, signaling protein, disulfide constrained peptide, wnt agonism
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 79297.82

Authors

Thakur, A.K.,Liau, N.P.D.,Sudhamsu, J.,Hannoush, R.N. (deposition date: 2022-07-29, release date: 2023-03-29, Last modification date: 2023-11-15)

• Primary citation: Thakur, A.K.,Miller, S.E.,Liau, N.P.D.,Hwang, S.,Hansen, S.,de Sousa E Melo, F.,Sudhamsu, J.,Hannoush, R.N.; Synthetic Multivalent Disulfide-Constrained Peptide Agonists Potentiate Wnt1/ beta-Catenin Signaling via LRP6 Coreceptor Clustering.; Acs Chem.Biol., 18:772-784, 2023; PubMed: 36893429; DOI: 10.1021/acschembio.2c00753

Experimental method

X-RAY DIFFRACTION (2 Å)