8DVM
Crystal structure of LRP6 E3E4 in complex with disulfide constrained peptide E3.6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Low-density lipoprotein receptor-related protein 6 | polymer | 633 | 71774.6 | 1 | UniProt (O75581) Pfam (PF00058) Pfam (PF14670) | Homo sapiens (human) | LRP-6 |
| 2 | B (B) | E3.6 Disulfide constrained peptide | polymer | 30 | 3470.1 | 1 | synthetic construct | ||
| 3 | C (F) | alpha-L-fucopyranose-(1-3)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-3)][alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1212.2 | 1 | In PDB | |||
| 4 | D, E (C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 5 | F (E) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 6 | G (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 7 | H, I, J (A) | CALCIUM ION | non-polymer | 40.1 | 3 | Chemie (CA) | |||
| 8 | K, L, M, N, O... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 14 | Chemie (EDO) | |||
| 9 | Y (A) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
| 10 | AA, Z (B, A) | water | water | 18.0 | 224 | Chemie (HOH) |
Sequence modifications
A: 631 - 1253 (UniProt: O75581)
| PDB | External Database | Details |
|---|---|---|
| Ser 630 | - | expression tag |
| Ile 1062 | Val 1062 | variant |
| Gly 1254 | - | expression tag |
| Asn 1255 | - | expression tag |
| Ser 1256 | - | expression tag |
| His 1257 | - | expression tag |
| His 1258 | - | expression tag |
| His 1259 | - | expression tag |
| His 1260 | - | expression tag |
| His 1261 | - | expression tag |
| His 1262 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 75244.7 | |
| Branched | Number of molecules | 4 |
| Total formula weight | 2647.5 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 1405.6 | |
| All* | Total formula weight | 79297.8 |
