7C7Q
 
 | | Cryo-EM structure of the baclofen/BHFF-bound human GABA(B) receptor in active state | | Descriptor: | (3S)-5,7-ditert-butyl-3-oxidanyl-3-(trifluoromethyl)-1-benzofuran-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid type B receptor subunit 1, ... | | Authors: | Mao, C, Shen, C, Li, C, Shen, D, Xu, C, Zhang, S, Zhou, R, Shen, Q, Chen, L, Jiang, Z, Liu, J, Zhang, Y. | | Deposit date: | 2020-05-26 | | Release date: | 2020-07-01 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Cryo-EM structures of inactive and active GABABreceptor.
Cell Res., 30, 2020
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7C7S
 | | Cryo-EM structure of the CGP54626-bound human GABA(B) receptor in inactive state. | | Descriptor: | (R)-(cyclohexylmethyl)[(2S)-3-{[(1S)-1-(3,4-dichlorophenyl)ethyl]amino}-2-hydroxypropyl]phosphinic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid type B receptor subunit 1, ... | | Authors: | Mao, C, Shen, C, Li, C, Shen, D, Xu, C, Zhang, S, Zhou, R, Shen, Q, Chen, L, Jiang, Z, Liu, J, Zhang, Y. | | Deposit date: | 2020-05-26 | | Release date: | 2020-07-01 | | Last modified: | 2020-07-29 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Cryo-EM structures of inactive and active GABABreceptor.
Cell Res., 30, 2020
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7EB6
 | | Crystal structure of GTP-binding protein-like domain of AGAP1 | | Descriptor: | Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 | | Authors: | Cheng, N, Zhang, H, Zhang, S, Ma, X, Meng, G. | | Deposit date: | 2021-03-09 | | Release date: | 2021-04-21 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.014 Å) | | Cite: | Crystal structure of the GTP-binding protein-like domain of AGAP1.
Acta Crystallogr.,Sect.F, 77, 2021
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7X4B
 | | Crystal Structure of An Anti-CRISPR Protein | | Descriptor: | Anti-CRISPR protein (AcrIIC1), SULFATE ION | | Authors: | Hu, J, Zhang, S, Gao, J.Y, Liu, X, Liu, J. | | Deposit date: | 2022-03-02 | | Release date: | 2022-10-26 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (1.61 Å) | | Cite: | A redox switch regulates the assembly and anti-CRISPR activity of AcrIIC1.
Nat Commun, 13, 2022
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7BPI
 | | The crystal structue of PDE10A complexed with 14 | | Descriptor: | 8-[(E)-2-[5-methyl-1-[3-[3-(4-methylpiperazin-1-yl)propoxy]phenyl]benzimidazol-2-yl]ethenyl]quinoline, MAGNESIUM ION, ZINC ION, ... | | Authors: | Yang, Y, Zhang, S, Zhou, Q, Huang, Y.-Y, Guo, L, Luo, H.-B. | | Deposit date: | 2020-03-22 | | Release date: | 2021-01-27 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.4000864 Å) | | Cite: | Discovery of highly selective and orally available benzimidazole-based phosphodiesterase 10 inhibitors with improved solubility and pharmacokinetic properties for treatment of pulmonary arterial hypertension.
Acta Pharm Sin B, 10, 2020
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7VUL
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7VH2
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7VGQ
 | | Cryo-EM structure of Machupo virus polymerase L in complex with matrix protein Z | | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,RING finger protein Z, RNA-directed RNA polymerase L, ZINC ION | | Authors: | Zhang, X, Ma, J, Zhang, S. | | Deposit date: | 2021-09-18 | | Release date: | 2021-09-29 | | Last modified: | 2022-03-02 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Structure of Machupo virus polymerase in complex with matrix protein Z.
Nat Commun, 12, 2021
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7VH1
 | | Cryo-EM structure of Machupo virus dimeric L-Z complex | | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,RING finger protein Z, RNA-directed RNA polymerase L, ZINC ION | | Authors: | Zhang, X, Ma, J, Zhang, S. | | Deposit date: | 2021-09-20 | | Release date: | 2021-09-29 | | Last modified: | 2022-03-02 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Structure of Machupo virus polymerase in complex with matrix protein Z.
Nat Commun, 12, 2021
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7VH3
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7C2S
 | | Helical reconstruction of Dengue virus serotype 3 complexed with Fab C10 | | Descriptor: | Heavy chain of Fab C10, envelope protein, light chain of Fab C10 | | Authors: | Morrone, S, Chew, S.V, Lim, X.N, Ng, T.S, Kostyuchenko, V.A, Zhang, S, Lok, S.M. | | Deposit date: | 2020-05-09 | | Release date: | 2020-07-08 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (10.4 Å) | | Cite: | High flavivirus structural plasticity demonstrated by a non-spherical morphological variant.
Nat Commun, 11, 2020
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7C2T
 | | Helical reconstruction of Zika virus complexed with Fab C10 | | Descriptor: | Heavy chain from Fab C10, Light chain from Fab C10, M protein, ... | | Authors: | Morrone, S, Chew, S.V, Lim, X.N, Ng, T.S, Kostyuchenko, V.A, Zhang, S, Lok, S.M. | | Deposit date: | 2020-05-09 | | Release date: | 2020-07-08 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (9.4 Å) | | Cite: | High flavivirus structural plasticity demonstrated by a non-spherical morphological variant.
Nat Commun, 11, 2020
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7VPP
 | | Structures of a deltacoronavirus spike protein bound to porcine and human receptors indicate the risk of virus adaptation to humans | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Ji, W, Xu, Y, Zhang, S. | | Deposit date: | 2021-10-17 | | Release date: | 2022-03-16 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.69 Å) | | Cite: | Structures of a deltacoronavirus spike protein bound to porcine and human receptors.
Nat Commun, 13, 2022
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7VPQ
 | | Structures of a deltacoronavirus spike protein bound to porcine and human receptors indicate the risk of virus adaptation to humans | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Ji, W, Xu, Y, Zhang, S. | | Deposit date: | 2021-10-17 | | Release date: | 2022-03-16 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structures of a deltacoronavirus spike protein bound to porcine and human receptors.
Nat Commun, 13, 2022
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7KZ7
 | | Crystals Structure of the Mutated Protease Domain of Botulinum Neurotoxin X (X4130B1). | | Descriptor: | 1,2-ETHANEDIOL, Botulinum neurotoxin type X, GLYCEROL, ... | | Authors: | Blum, T.R, Liu, H, Packer, M.S, Xiong, X, Lee, P.G, Zhang, S, Richter, M, Minasov, G, Satchell, K.J.F, Dong, M, Liu, D.R, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2020-12-10 | | Release date: | 2020-12-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Phage-assisted evolution of botulinum neurotoxin proteases with reprogrammed specificity.
Science, 371, 2021
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7CKR
 | | Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate BAY-8002 in the outward-open conformation. | | Descriptor: | 2-[[2-chloranyl-5-(phenylsulfonyl)phenyl]carbonylamino]benzoic acid, Basigin, Monocarboxylate transporter 1 | | Authors: | Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C. | | Deposit date: | 2020-07-18 | | Release date: | 2020-12-23 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.
Cell, 184, 2021
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7CKO
 | | Cryo-EM structure of the human MCT1/Basigin-2 complex in the presence of anti-cancer drug candidate 7ACC2 in the inward-open conformation | | Descriptor: | 7-[methyl-(phenylmethyl)amino]-2-oxidanylidene-chromene-3-carboxylic acid, Basigin, Monocarboxylate transporter 1 | | Authors: | Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C. | | Deposit date: | 2020-07-18 | | Release date: | 2020-12-23 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (2.95 Å) | | Cite: | Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.
Cell, 184, 2021
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7DA5
 | | Cryo-EM structure of the human MCT1 D309N mutant in complex with Basigin-2 in the inward-open conformation. | | Descriptor: | Basigin, Monocarboxylate transporter 1 | | Authors: | Wang, N, Jiang, X, Zhang, S, Zhu, A, Yuan, Y, Lei, J, Yan, C. | | Deposit date: | 2020-10-14 | | Release date: | 2020-12-23 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of human monocarboxylate transporter 1 inhibition by anti-cancer drug candidates.
Cell, 184, 2021
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7V3F
 | | DENV2_NGC_Fab_C10 28degree (1Fab:3E) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope protein E, ... | | Authors: | Shu, B, Zhang, S, Victor, A.K, Ng, T.S, Lok, S.M. | | Deposit date: | 2021-08-10 | | Release date: | 2021-12-29 | | Method: | ELECTRON MICROSCOPY (3.7 Å) | | Cite: | Human antibody C10 neutralizes by diminishing Zika but enhancing dengue virus dynamics.
Cell, 184, 2021
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7V3G
 | | DENV2_NGC_Fab_C10 28degrees (2Fab:3E) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope protein E, ... | | Authors: | Shu, B, Zhang, S, Victor, A.K, Ng, T.S, Lok, S.M. | | Deposit date: | 2021-08-10 | | Release date: | 2021-12-29 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Human antibody C10 neutralizes by diminishing Zika but enhancing dengue virus dynamics.
Cell, 184, 2021
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7V3H
 | | DENV2_NGC_Fab_C10 28degrees (3Fab:3E) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, C10 IgG heavy chain variable region, ... | | Authors: | Shu, B, Zhang, S, Victor, A.K, Ng, T.S, Lok, S.M. | | Deposit date: | 2021-08-10 | | Release date: | 2021-12-29 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Human antibody C10 neutralizes by diminishing Zika but enhancing dengue virus dynamics.
Cell, 184, 2021
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7V3I
 | | DENV2_NGC_Fab_C10 4degrees (3Fab:3E) | | Descriptor: | Envelope protein E, Fab_C10_heavy_chain, Fab_C10_light_chain, ... | | Authors: | Shu, B, Zhang, S, Victor, A.K, Ng, T.S, Lok, S.M. | | Deposit date: | 2021-08-10 | | Release date: | 2021-12-29 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Human antibody C10 neutralizes by diminishing Zika but enhancing dengue virus dynamics.
Cell, 184, 2021
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7V3J
 | | DENV2:F(ab')2-local | | Descriptor: | Envelope protein E, Fab_C10_heavy_chain, Fab_C10_light_chain, ... | | Authors: | Shu, B, Zhang, S, Victor, A.K, Ng, T.S, Lok, S.M. | | Deposit date: | 2021-08-10 | | Release date: | 2021-12-29 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (4.9 Å) | | Cite: | Human antibody C10 neutralizes by diminishing Zika but enhancing dengue virus dynamics.
Cell, 184, 2021
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7V5K
 | | MERS S ectodomain trimer in complex with neutralizing antibody 0722 (state 1) | | Descriptor: | 0722 H, 0722 L, Spike glycoprotein | | Authors: | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | | Deposit date: | 2021-08-17 | | Release date: | 2022-08-24 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 0722 (state 1)
to be published
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7V5J
 | | MERS S ectodomain trimer in complex with neutralizing antibody 0722(state 2) | | Descriptor: | 0722 H, 0722 L, Spike glycoprotein | | Authors: | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | | Deposit date: | 2021-08-17 | | Release date: | 2022-09-21 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 0722(state 2)
to be published
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