7BPI

The crystal structue of PDE10A complexed with 14

Summary for 7BPI

• Entry DOI: 10.2210/pdb7bpi/pdb
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: pde10a inhibitor, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 75276.95

Authors

Yang, Y.,Zhang, S.,Zhou, Q.,Huang, Y.-Y.,Guo, L.,Luo, H.-B. (deposition date: 2020-03-22, release date: 2021-01-27, Last modification date: 2023-11-29)

• Primary citation: Yang, Y.,Zhang, S.,Zhou, Q.,Zhang, C.,Gao, Y.,Wang, H.,Li, Z.,Wu, D.,Wu, Y.,Huang, Y.Y.,Guo, L.,Luo, H.B.; Discovery of highly selective and orally available benzimidazole-based phosphodiesterase 10 inhibitors with improved solubility and pharmacokinetic properties for treatment of pulmonary arterial hypertension.; Acta Pharm Sin B, 10:2339-2347, 2020; PubMed: 33354505; DOI: 10.1016/j.apsb.2020.04.003

Experimental method

X-RAY DIFFRACTION (2.40008632403 Å)