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6K1N
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BU of 6k1n by Molmil
PLP-bound form of a putative cystathionine gamma-lyase
Descriptor: Cystathionine gamma-lyase, PYRIDOXAL-5'-PHOSPHATE
Authors:Chen, S, Wang, Y.
Deposit date:2019-05-10
Release date:2020-05-13
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural characterization of cystathionine gamma-lyase smCSE enables aqueous metal quantum dot biosynthesis.
Int.J.Biol.Macromol., 174, 2021
6KYQ
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BU of 6kyq by Molmil
Crystal structure of DCLK1 Autoinhibited Kinase Domain
Descriptor: BETA-MERCAPTOETHANOL, Serine/threonine-protein kinase DCLK1
Authors:Yu, Y, Chen, Q.
Deposit date:2019-09-20
Release date:2020-09-23
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.141 Å)
Cite:DCLK1 Autoinhibition and Activation in Tumorigenesis
Innovation (N Y), 2021
6KYR
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BU of 6kyr by Molmil
Crystal structure of DCLK1 mutant (P675L) Autoinhibited Kinase Domain
Descriptor: BETA-MERCAPTOETHANOL, Serine/threonine-protein kinase DCLK1
Authors:Yu, Y, Chen, Q.
Deposit date:2019-09-20
Release date:2020-09-23
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.206 Å)
Cite:DCLK1 Autoinhibition and Activation in Tumorigenesis
Innovation (N Y), 2021
2PVC
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BU of 2pvc by Molmil
DNMT3L recognizes unmethylated histone H3 lysine 4
Descriptor: DNA (cytosine-5)-methyltransferase 3-like, Histone H3 peptide, ZINC ION
Authors:Cheng, X.
Deposit date:2007-05-09
Release date:2007-08-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.69 Å)
Cite:DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.
Nature, 448, 2007
2PV0
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BU of 2pv0 by Molmil
DNA methyltransferase 3 like protein (DNMT3L)
Descriptor: DNA (cytosine-5)-methyltransferase 3-like, ZINC ION
Authors:Cheng, X.
Deposit date:2007-05-09
Release date:2007-08-14
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:DNMT3L connects unmethylated lysine 4 of histone H3 to de novo methylation of DNA.
Nature, 448, 2007
3LKH
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BU of 3lkh by Molmil
Inhibitors of Hepatitis C Virus Polymerase: Synthesis and Characterization of Novel 6-Fluoro-N-[2-Hydroxy-1(S)-Benzamides
Descriptor: 2-(2-{[(1S)-1-benzyl-2-hydroxyethyl]amino}-2-oxoethoxy)-N-butyl-6-fluoro-N-methylbenzamide, RNA-directed RNA polymerase
Authors:Lesburg, C.A.
Deposit date:2010-01-27
Release date:2010-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Inhibitors of hepatitis C virus polymerase: synthesis and characterization of novel 2-oxy-6-fluoro-N-((S)-1-hydroxy-3-phenylpropan-2-yl)-benzamides.
Bioorg.Med.Chem.Lett., 20, 2010
7XHO
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BU of 7xho by Molmil
Structure of human inner kinetochore CCAN complex
Descriptor: CENP-W, Centromere protein C, Centromere protein H, ...
Authors:Tian, T, Wang, C.L, Yang, Z.S, Sun, L.F, Zang, J.Y.
Deposit date:2022-04-09
Release date:2022-12-14
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:Structural insights into human CCAN complex assembled onto DNA.
Cell Discov, 8, 2022
7XHN
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BU of 7xhn by Molmil
Structure of human inner kinetochore CCAN-DNA complex
Descriptor: CENP-W, Centromere protein C, Centromere protein H, ...
Authors:Sun, L.F, Tian, T, Wang, C.L, Yang, Z.S, Zang, J.Y.
Deposit date:2022-04-09
Release date:2023-01-25
Method:ELECTRON MICROSCOPY (3.71 Å)
Cite:Structural insights into human CCAN complex assembled onto DNA.
Cell Discov, 8, 2022
8JZR
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BU of 8jzr by Molmil
Outward_facing SLC15A4 monomer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, lysosomal transporter,ALFA tag
Authors:Zhang, S.S, Chen, X.D, Xie, M.
Deposit date:2023-07-06
Release date:2023-09-27
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling.
Nat Commun, 14, 2023
8JZU
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BU of 8jzu by Molmil
SLC15A4_TASL complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, TLR adapter interacting with SLC15A4 on the lysosome, lysosomal transporter
Authors:Zhang, S.S, Chen, X.D, Xie, M.
Deposit date:2023-07-06
Release date:2023-09-27
Last modified:2023-11-01
Method:ELECTRON MICROSCOPY (3.05 Å)
Cite:Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling.
Nat Commun, 14, 2023
8JZS
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BU of 8jzs by Molmil
Outward-facing SLC15A4 dimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, lysosomal transporter
Authors:Zhang, S.S, Chen, X.D, Xie, M.
Deposit date:2023-07-06
Release date:2023-09-27
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (2.95 Å)
Cite:Structural basis for recruitment of TASL by SLC15A4 in human endolysosomal TLR signaling.
Nat Commun, 14, 2023
5JZV
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BU of 5jzv by Molmil
The structure of D77G hCINAP-ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Adenylate kinase isoenzyme 6
Authors:Liu, Y, Yang, Z, Yang, Y, Cai, X, Zheng, X.
Deposit date:2016-05-17
Release date:2016-08-10
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth.
Nat Commun, 7, 2016
7X2M
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BU of 7x2m by Molmil
Crystal structure of nanobody 1-2C7 with SARS-CoV-2 RBD
Descriptor: 1-2C7, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-D-mannopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Spike protein S1
Authors:Wang, X.Q, Zhang, L.Q, Ren, Y.F, Li, M.X.
Deposit date:2022-02-25
Release date:2022-12-14
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses.
Nat Commun, 13, 2022
7X2L
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BU of 7x2l by Molmil
Crystal structure of nanobody 3-2A2-4 with SARS-CoV-2 RBD
Descriptor: Nanobody 3-2A2-4, Spike protein S1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Wang, X.Q, Zhang, L.Q, Ren, Y.F, Li, M.X.
Deposit date:2022-02-25
Release date:2022-12-07
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses.
Nat Commun, 13, 2022
7X2J
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BU of 7x2j by Molmil
Crystal structure of nanobody Nb70 with SARS-CoV RBD
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Nb70, Spike protein S1
Authors:Wang, X.Q, Zhang, L.Q, Ren, Y.F, Li, M.X.
Deposit date:2022-02-25
Release date:2022-12-21
Last modified:2023-06-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses.
Nat Commun, 13, 2022
7X2K
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BU of 7x2k by Molmil
Crystal structure of nanobody Nb70 with antibody 1F11 fab and SARS-CoV-2 RBD
Descriptor: 1F11-H, 1F11-L, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Wang, X.Q, Zhang, L.Q, Ren, Y.F, Li, M.X.
Deposit date:2022-02-25
Release date:2022-12-21
Last modified:2023-06-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Broadly neutralizing and protective nanobodies against SARS-CoV-2 Omicron subvariants BA.1, BA.2, and BA.4/5 and diverse sarbecoviruses.
Nat Commun, 13, 2022
7XKE
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BU of 7xke by Molmil
Cryo-EM structure of DHEA-ADGRG2-FL-Gs complex
Descriptor: 3-BETA-HYDROXY-5-ANDROSTEN-17-ONE, Adhesion G-protein coupled receptor G2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Guo, S.C, Xiao, P, Lin, H, Sun, J.P, Yu, X.
Deposit date:2022-04-19
Release date:2022-08-10
Last modified:2023-03-15
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structures of the ADGRG2-G s complex in apo and ligand-bound forms.
Nat.Chem.Biol., 18, 2022
7XKF
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BU of 7xkf by Molmil
Cryo-EM structure of DHEA-ADGRG2-BT-Gs complex at lower state
Descriptor: 3-BETA-HYDROXY-5-ANDROSTEN-17-ONE, Adhesion G-protein coupled receptor G2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Guo, S.C, Xiao, P, Lin, H, Sun, J.P, Yu, X.
Deposit date:2022-04-19
Release date:2022-08-10
Last modified:2023-03-15
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structures of the ADGRG2-G s complex in apo and ligand-bound forms.
Nat.Chem.Biol., 18, 2022
7XKD
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BU of 7xkd by Molmil
Cryo-EM structure of DHEA-ADGRG2-BT-Gs complex
Descriptor: 3-BETA-HYDROXY-5-ANDROSTEN-17-ONE, Adhesion G-protein coupled receptor G2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Guo, S.C, Xiao, P, Lin, H, Sun, J.P, Yu, X.
Deposit date:2022-04-19
Release date:2022-08-10
Last modified:2023-03-15
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Structures of the ADGRG2-G s complex in apo and ligand-bound forms.
Nat.Chem.Biol., 18, 2022
5WOE
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BU of 5woe by Molmil
Solution structure of the sorting nexin 25 phox-homology domain
Descriptor: Sorting nexin-25
Authors:Chin, Y.K.Y, Mas, C, Mobli, M, Collins, B.M.
Deposit date:2017-08-01
Release date:2018-08-08
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Classification of the human phox homology (PX) domains based on their phosphoinositide binding specificities.
Nat Commun, 10, 2019
6IHB
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BU of 6ihb by Molmil
Adeno-Associated Virus 2 in complex with AAVR
Descriptor: Capsid protein VP1, Dyslexia-associated protein KIAA0319-like protein
Authors:Lou, Z.Y, Zhang, R.
Deposit date:2018-09-29
Release date:2019-03-20
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Adeno-associated virus 2 bound to its cellular receptor AAVR.
Nat Microbiol, 4, 2019
6IH9
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BU of 6ih9 by Molmil
Adeno-Associated Virus 2 at 2.8 ang
Descriptor: Capsid protein VP1
Authors:Lou, Z.Y, Zhang, R.
Deposit date:2018-09-29
Release date:2019-07-03
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Adeno-associated virus 2 bound to its cellular receptor AAVR.
Nat Microbiol, 4, 2019
5QIN
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BU of 5qin by Molmil
TGF-BETA RECEPTOR TYPE 2 KINASE DOMAIN IN COMPLEX WITH N- {4-[3-(6-METHOXYPYRIDIN-3-YL)-1H-PYRROLO[3,2-B]PYRIDIN-2- YL]PYRIDIN-2-YL}ACETAMIDE
Descriptor: GLYCEROL, MAGNESIUM ION, N-{4-[3-(6-methoxypyridin-3-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamide, ...
Authors:Sheriff, S.
Deposit date:2018-08-05
Release date:2018-10-31
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Discovery of 4-Azaindole Inhibitors of TGF beta RI as Immuno-oncology Agents.
ACS Med Chem Lett, 9, 2018
5QIM
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BU of 5qim by Molmil
TGF-BETA RECEPTOR TYPE 1 KINASE DOMAIN (T204D) IN COMPLEX WITH N-{4-[3-(5-METHOXYPYRIDIN-2-YL)-1H-PYRROLO[3,2-B] PYRIDIN-2-YL]PYRIDIN-2-YL}ACETAMIDE
Descriptor: GLYCEROL, N-{4-[3-(5-methoxypyridin-2-yl)-1H-pyrrolo[3,2-b]pyridin-2-yl]pyridin-2-yl}acetamide, TGF-beta receptor type-1
Authors:Sheriff, S.
Deposit date:2018-08-05
Release date:2018-10-31
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Discovery of 4-Azaindole Inhibitors of TGF beta RI as Immuno-oncology Agents.
ACS Med Chem Lett, 9, 2018
4NQQ
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BU of 4nqq by Molmil
Crystal structure of mouse P-cadherin extracellular domains EC1-EC2
Descriptor: CALCIUM ION, COPPER (II) ION, Cadherin-3
Authors:Brasch, J, Shapiro, L.
Deposit date:2013-11-25
Release date:2014-09-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural and energetic determinants of adhesive binding specificity in type I cadherins.
Proc.Natl.Acad.Sci.USA, 111, 2014

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