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6IDF
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BU of 6idf by Molmil
Cryo-EM structure of gamma secretase in complex with a Notch fragment
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Yang, G, Zhou, R, Zhou, Q, Guo, X, Yan, C, Ke, M, Lei, J, Shi, Y.
登録日2018-09-09
公開日2018-12-26
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural basis of Notch recognition by human gamma-secretase
Nature, 565, 2019
7C9I
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BU of 7c9i by Molmil
Human gamma-secretase in complex with small molecule L-685,458
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Yang, G, Zhou, R, Guo, X, Lei, J, Yan, C, Shi, Y.
登録日2020-06-05
公開日2021-01-27
最終更新日2021-02-03
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.
Cell, 184, 2021
7D8X
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BU of 7d8x by Molmil
CryoEM structure of human gamma-secretase in complex with E2012 and L685458
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]methylidene]piperidin-2-one, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Yang, G, Zhou, R, Guo, X, Lei, J, Yan, C, Shi, Y.
登録日2020-10-11
公開日2021-01-27
最終更新日2021-02-03
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.
Cell, 184, 2021
6LQG
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BU of 6lqg by Molmil
Human gamma-secretase in complex with small molecule Avagacestat
分子名称: (2R)-2-[(4-chlorophenyl)sulfonyl-[[2-fluoranyl-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-tris(fluoranyl)pentanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Yang, G, Zhou, R, Guo, X, Lei, J, Shi, Y.
登録日2020-01-13
公開日2021-01-27
最終更新日2021-02-03
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.
Cell, 184, 2021
6LR4
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BU of 6lr4 by Molmil
Molecular basis for inhibition of human gamma-secretase by small molecule
分子名称: (2S)-2-hydroxy-3-methyl-N-[(2S)-1-[[(5S)-3-methyl-4-oxo-2,5-dihydro-1H-3-benzazepin-5-yl]amino]-1-oxopropan-2-yl]butanamide, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Yang, G, Zhou, R, Guo, X, Lei, J, Shi, Y.
登録日2020-01-15
公開日2021-01-27
最終更新日2021-02-03
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structural basis of gamma-secretase inhibition and modulation by small molecule drugs.
Cell, 184, 2021
5AFX
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BU of 5afx by Molmil
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-1238
分子名称: FARNESYL PYROPHOSPHATE SYNTHASE, MAGNESIUM ION, [1-hydroxy-2-(1-nonyl-1H-3lambda~5~-imidazol-3-yl)ethane-1,1-diyl]bis(phosphonic acid)
著者Yang, G, Oldfield, E, No, J.H.
登録日2015-01-27
公開日2015-10-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.39 Å)
主引用文献Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation.
Antimicrob.Agents Chemother., 59, 2015
5AEL
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BU of 5ael by Molmil
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-597
分子名称: FARNESYL PYROPHOSPHATE SYNTHASE, MAGNESIUM ION, {2-[3-(hex-1-yn-1-yl)pyridinium-1-yl]ethane-1,1-diyl}bis(phosphonate)
著者Yang, G, Oldfield, E, No, J.H.
登録日2014-12-26
公開日2015-10-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation.
Antimicrob.Agents Chemother., 59, 2015
5AHU
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BU of 5ahu by Molmil
T. Brucei Farnesyl Diphosphate Synthase Complexed with Bisphosphonate BPH-1326
分子名称: FARNESYL PYROPHOSPHATE SYNTHASE, PUTATIVE, MAGNESIUM ION, ...
著者Yang, G, Oldfield, E, No, J.H.
登録日2015-02-09
公開日2015-10-28
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.69 Å)
主引用文献Inhibition of Trypanosoma Brucei Cell Growth by Lipophilic Bisphosphonates: An in Vitro and in Vivo Investigation.
Antimicrob.Agents Chemother., 59, 2015
7F09
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BU of 7f09 by Molmil
Crystal structure of the HLH-Lz domain of human TFE3
分子名称: 1,2-ETHANEDIOL, Transcription factor E3, ZINC ION
著者Yang, G, Li, P, Liu, Z, Wu, S, Zhuang, C, Qiao, H, Fang, P, Wang, J.
登録日2021-06-03
公開日2021-07-21
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural basis for the dimerization mechanism of human transcription factor E3.
Biochem.Biophys.Res.Commun., 569, 2021
9CGI
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BU of 9cgi by Molmil
Cryo-EM structure of the Nipah Virus polymerase (L) protein in complex with the tetrameric phosphoprotein (P)
分子名称: Phosphoprotein, RNA-directed RNA polymerase L
著者Liu, B, Yang, G, Wang, D.
登録日2024-06-29
公開日2024-09-18
実験手法ELECTRON MICROSCOPY (2.92 Å)
主引用文献Structure of the Nipah virus polymerase phosphoprotein complex.
Nat Commun, 2024
6C2C
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BU of 6c2c by Molmil
The molecular basis for the functional evolution of an organophosphate hydrolysing enzyme
分子名称: DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ZINC ION, ...
著者Hong, N.-S, Jackson, C.J, Carr, P.D, Tokuriki, N, Baier, F, Yang, G.
登録日2018-01-08
公開日2019-01-16
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.597 Å)
主引用文献Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme.
Nat.Chem.Biol., 15, 2019
5EH9
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BU of 5eh9 by Molmil
Indirect contributions of mutations underlie optimization of new enzyme function
分子名称: 2-HYDROXYETHYL DISULFIDE, GLYCEROL, N-acyl homoserine lactonase AiiA, ...
著者Hong, N.-S, Jackson, C.J, Tokuriki, N, Yang, G, Baier, F.
登録日2015-10-28
公開日2016-09-07
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.29 Å)
主引用文献Conformational Tinkering Drives Evolution of a Promiscuous Activity through Indirect Mutational Effects.
Biochemistry, 55, 2016
3S0R
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BU of 3s0r by Molmil
Crystal Structure of De novo Designed helical assembly protein
分子名称: De novo designed Helical Assembly
著者Acharya, R, Grigoryan, G, Kim, Y.H, DeGrado, W.F.
登録日2011-05-13
公開日2011-06-15
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.453 Å)
主引用文献Computational design of virus-like protein assemblies on carbon nanotube surfaces.
Science, 332, 2011
7Y62
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BU of 7y62 by Molmil
Crystal structure of human TFEB HLHLZ domain
分子名称: Transcription factor EB
著者Yang, G, Li, P, Lin, Y, Liu, Z, Sun, H, Zhao, Z, Fang, P, Wang, J.
登録日2022-06-18
公開日2023-03-22
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB.
Proc.Natl.Acad.Sci.USA, 120, 2023
4R12
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BU of 4r12 by Molmil
Crystal structure of the gamma-secretase component Nicastrin
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
著者Xie, T, Yan, C, Zhou, R, Zhao, Y, Sun, L, Yang, G, Lu, P, Ma, D, Shi, Y.
登録日2014-08-03
公開日2014-09-17
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Crystal structure of the gamma-secretase component nicastrin.
Proc.Natl.Acad.Sci.USA, 111, 2014
4UIS
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BU of 4uis by Molmil
The cryoEM structure of human gamma-Secretase complex
分子名称: GAMMA-SECRETASE, LYSOZYME
著者Sun, L, Zhao, L, Yang, G, Yan, C, Zhou, R, Zhou, X, Xie, T, Zhao, Y, Wu, S, Li, X, Shi, Y.
登録日2015-04-03
公開日2015-06-10
最終更新日2017-08-02
実験手法ELECTRON MICROSCOPY (4.4 Å)
主引用文献Structural Basis of Human Gamma-Secretase Assembly.
Proc.Natl.Acad.Sci.USA, 112, 2015
5A63
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BU of 5a63 by Molmil
Cryo-EM structure of the human gamma-secretase complex at 3.4 angstrom resolution.
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Bai, X, Yan, C, Yang, G, Lu, P, Ma, D, Sun, L, Zhou, R, Scheres, S.H.W, Shi, Y.
登録日2015-06-24
公開日2015-08-05
最終更新日2020-07-29
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献An Atomic Structure of Human Gamma-Secretase
Nature, 525, 2015
8X7Z
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BU of 8x7z by Molmil
Crystal structure of CCoV-HuPn-2018 fusion core
分子名称: HR1, HR2
著者Yan, L, Yang, G.
登録日2023-11-26
公開日2024-05-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal Structures of Fusion Cores from CCoV-HuPn-2018 and SADS-CoV.
Viruses, 16, 2024
5DKZ
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BU of 5dkz by Molmil
Crystal structure of glucosidase II alpha subunit (alpha3-Glc2-bound from)
分子名称: Alpha glucosidase-like protein, alpha-D-glucopyranose-(1-3)-alpha-D-glucopyranose
著者Satoh, T, Toshimori, T, Yan, G, Yamaguchi, T, Kato, K.
登録日2015-09-04
公開日2016-01-27
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for two-step glucose trimming by glucosidase II involved in ER glycoprotein quality control.
Sci Rep, 6, 2016
5DKX
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BU of 5dkx by Molmil
Crystal structure of glucosidase II alpha subunit (Tris-bound from)
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Alpha glucosidase-like protein, CHLORIDE ION
著者Satoh, T, Toshimori, T, Yan, G, Yamaguchi, T, Kato, K.
登録日2015-09-04
公開日2016-01-27
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural basis for two-step glucose trimming by glucosidase II involved in ER glycoprotein quality control.
Sci Rep, 6, 2016
5DL0
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BU of 5dl0 by Molmil
Crystal structure of glucosidase II alpha subunit (Glc1Man2-bound from)
分子名称: Alpha glucosidase-like protein, alpha-D-glucopyranose-(1-3)-alpha-D-mannopyranose
著者Satoh, T, Toshimori, T, Yan, G, Yamaguchi, T, Kato, K.
登録日2015-09-04
公開日2016-01-27
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for two-step glucose trimming by glucosidase II involved in ER glycoprotein quality control.
Sci Rep, 6, 2016
5DKY
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BU of 5dky by Molmil
Crystal structure of glucosidase II alpha subunit (DNJ-bound from)
分子名称: 1-DEOXYNOJIRIMYCIN, Alpha glucosidase-like protein
著者Satoh, T, Toshimori, T, Yan, G, Yamaguchi, T, Kato, K.
登録日2015-09-04
公開日2016-01-27
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural basis for two-step glucose trimming by glucosidase II involved in ER glycoprotein quality control.
Sci Rep, 6, 2016
7YD3
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BU of 7yd3 by Molmil
Single-chain variable fragment of app 3D1 antibody
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Yan, L, Yang, G.
登録日2022-07-03
公開日2023-07-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Cross-reactive epitopes between HIV and Coronavirus revealed by 3D1
To Be Published
7YI6
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BU of 7yi6 by Molmil
bnAb 3D1 in complex with 6-mer HR1 peptide from HCoV-229E S protein
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Yan, L, Yang, G.
登録日2022-07-15
公開日2023-08-30
実験手法X-RAY DIFFRACTION (2.28 Å)
主引用文献Cross-reactive epitopes between HIV and Coronavirus revealed by 3D1
To Be Published
2ADU
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BU of 2adu by Molmil
Human Methionine Aminopeptidase Complex with 4-Aryl-1,2,3-triazole Inhibitor
分子名称: 4-(3-METHYLPHENYL)-1H-1,2,3-TRIAZOLE, COBALT (II) ION, Methionine aminopeptidase 2
著者Kallander, L.S, Lu, Q, Chen, W, Tomaszek, T, Yang, G, Tew, D, Meek, T.D, Hofmann, G.A, Schulz-Pritchard, C.K, Smith, W.W, Janson, C.A, Ryan, M.D, Zhang, G.F, Johanson, K.O, Kirkpatrick, R.B, Ho, T.F, Fisher, P.W, Mattern, M.R, Johnson, R.K, Hansbury, M.J, Winkler, J.D, Ward, K.W, Veber, D.F, Thompson, S.K.
登録日2005-07-20
公開日2005-09-13
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献4-Aryl-1,2,3-triazole: A Novel Template for a Reversible Methionine Aminopeptidase 2 Inhibitor, Optimized To Inhibit Angiogenesis in Vivo
J.Med.Chem., 48, 2005

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