2ADU
Human Methionine Aminopeptidase Complex with 4-Aryl-1,2,3-triazole Inhibitor
Summary for 2ADU
Entry DOI | 10.2210/pdb2adu/pdb |
Descriptor | Methionine aminopeptidase 2, COBALT (II) ION, 4-(3-METHYLPHENYL)-1H-1,2,3-TRIAZOLE, ... (4 entities in total) |
Functional Keywords | hydrolase, aminopeptidase, metal binding, protease |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm : P50579 |
Total number of polymer chains | 1 |
Total formula weight | 41647.06 |
Authors | Kallander, L.S.,Lu, Q.,Chen, W.,Tomaszek, T.,Yang, G.,Tew, D.,Meek, T.D.,Hofmann, G.A.,Schulz-Pritchard, C.K.,Smith, W.W.,Janson, C.A.,Ryan, M.D.,Zhang, G.F.,Johanson, K.O.,Kirkpatrick, R.B.,Ho, T.F.,Fisher, P.W.,Mattern, M.R.,Johnson, R.K.,Hansbury, M.J.,Winkler, J.D.,Ward, K.W.,Veber, D.F.,Thompson, S.K. (deposition date: 2005-07-20, release date: 2005-09-13, Last modification date: 2023-08-23) |
Primary citation | Kallander, L.S.,Lu, Q.,Chen, W.,Tomaszek, T.,Yang, G.,Tew, D.,Meek, T.D.,Hofmann, G.A.,Schulz-Pritchard, C.K.,Smith, W.W.,Janson, C.A.,Ryan, M.D.,Zhang, G.F.,Johanson, K.O.,Kirkpatrick, R.B.,Ho, T.F.,Fisher, P.W.,Mattern, M.R.,Johnson, R.K.,Hansbury, M.J.,Winkler, J.D.,Ward, K.W.,Veber, D.F.,Thompson, S.K. 4-Aryl-1,2,3-triazole: A Novel Template for a Reversible Methionine Aminopeptidase 2 Inhibitor, Optimized To Inhibit Angiogenesis in Vivo J.Med.Chem., 48:5644-5647, 2005 Cited by PubMed: 16134930DOI: 10.1021/jm050408c PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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