2ADU

Human Methionine Aminopeptidase Complex with 4-Aryl-1,2,3-triazole Inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0006508	biological_process	proteolysis
A	0070006	molecular_function	metalloaminopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CO A 501

Chain	Residue
A	ASP251
A	ASP262
A	GLU459
A	CO502
A	R20906

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site_id	AC2
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CO A 502

Chain	Residue
A	CO501
A	R20906
A	ASP262
A	HIS331
A	GLU364
A	GLU459

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site_id	AC3
Number of Residues	12
Details	BINDING SITE FOR RESIDUE R20 A 906

Chain	Residue
A	HIS231
A	ASP251
A	ASP262
A	HIS331
A	HIS339
A	GLU364
A	HIS382
A	TYR444
A	GLU459
A	CO501
A	CO502
A	HOH671

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Functional Information from PROSITE/UniProt

site_id	PS01202
Number of Residues	17
Details	MAP_2 Methionine aminopeptidase subfamily 2 signature. DIcKIDfGtHISGriiD

Chain	Residue	Details
A	ASP246-ASP262

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:16540317

Chain	Residue	Details
A	HIS231
A	HIS339

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site_id	SWS_FT_FI2
Number of Residues	5
Details	BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_03175, ECO:0000269|PubMed:14534293, ECO:0000269|PubMed:16134930, ECO:0000269|PubMed:16540317, ECO:0000269|PubMed:17350258, ECO:0000269|PubMed:17636946

Chain	Residue	Details
A	ASP251
A	ASP262
A	HIS331
A	GLU364
A	GLU459

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Catalytic Information from CSA

site_id	CSA1
Number of Residues	2
Details	Annotated By Reference To The Literature 1a16

Chain	Residue	Details
A	LYS342
A	GLU364

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site_id	CSA2
Number of Residues	1
Details	Annotated By Reference To The Literature 1a16

Chain	Residue	Details
A	GLU364

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