8OKX
 
 | | Structure of cGAS in complex with SPSB3-ELOBC | | Descriptor: | Cyclic GMP-AMP synthase, Elongin-B, Elongin-C, ... | | Authors: | Xu, P.B, Ablasser, A. | | Deposit date: | 2023-03-29 | | Release date: | 2024-02-14 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation.
Nature, 627, 2024
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8JT8
 | | Crystal structure of 5-HT2AR in complex with (R)-IHCH-7179 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ... | | Authors: | Chen, Z, Fan, L, Wang, S. | | Deposit date: | 2023-06-21 | | Release date: | 2024-02-28 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Flexible scaffold-based cheminformatics approach for polypharmacological drug design.
Cell, 187, 2024
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6O8C
 | | Crystal structure of STING CTT in complex with TBK1 | | Descriptor: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein | | Authors: | Li, P, Zhao, B, Du, F. | | Deposit date: | 2019-03-09 | | Release date: | 2019-05-22 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.17 Å) | | Cite: | A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Nature, 569, 2019
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6O8B
 | | Crystal structure of STING CTD in complex with TBK1 | | Descriptor: | N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, Serine/threonine-protein kinase TBK1, Stimulator of interferon genes protein | | Authors: | Li, P, Zhao, B, Du, F. | | Deposit date: | 2019-03-09 | | Release date: | 2019-05-22 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | A conserved PLPLRT/SD motif of STING mediates the recruitment and activation of TBK1.
Nature, 569, 2019
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6X5A
 | | The mouse cGAS catalytic domain binding to human nucleosome that purified from HEK293T cells | | Descriptor: | Cyclic GMP-AMP synthase, DNA (natural), Histone H2A type 1, ... | | Authors: | Pengbiao, X, Pingwei, L, Baoyu, Z. | | Deposit date: | 2020-05-25 | | Release date: | 2020-09-16 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.36 Å) | | Cite: | The molecular basis of tight nuclear tethering and inactivation of cGAS.
Nature, 587, 2020
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6X59
 | | The mouse cGAS catalytic domain binding to human assembled nucleosome | | Descriptor: | Cyclic GMP-AMP synthase, DNA, Histone H2A type 1, ... | | Authors: | Pengbiao, X, Pingwei, L, Baoyu, Z. | | Deposit date: | 2020-05-25 | | Release date: | 2020-09-16 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | The molecular basis of tight nuclear tethering and inactivation of cGAS.
Nature, 587, 2020
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5GVT
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6IEW
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6IHJ
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8JGG
 | | CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist BAM8-22 | | Descriptor: | BAM8-22, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Sun, J.P, Xu, H.E, Ynag, F, Liu, Z.M, Guo, L.L, Zhang, Y.M, Fang, G.X, Tie, L, Zhuang, Y.M, Xue, C.Y. | | Deposit date: | 2023-05-20 | | Release date: | 2024-01-10 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Ligand recognition and G protein coupling of the human itch receptor MRGPRX1.
Nat Commun, 14, 2023
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8JGB
 | | CryoEM structure of Gi-coupled MRGPRX1 with peptide agonist CNF-Tx2 | | Descriptor: | Conorfamide-Tx2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Sun, J.P, Xu, H.E, Yang, F, Liu, Z.M, Guo, L.L, Zhang, Y.M, Fang, G.X, Tie, L, Zhuang, Y.M, Xue, C.Y. | | Deposit date: | 2023-05-20 | | Release date: | 2024-01-10 | | Method: | ELECTRON MICROSCOPY (2.84 Å) | | Cite: | Ligand recognition and G protein coupling of the human itch receptor MRGPRX1.
Nat Commun, 14, 2023
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8JGF
 | | CryoEM structure of Gq-coupled MRGPRX1 with peptide agonist BAM8-22 | | Descriptor: | BAM8-22, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Sun, J.P, Xu, H.E, Yang, F, Liu, Z.M, Guo, L.L, Zhang, Y.M, Fang, G.X, Tie, L, Zhuang, Y.M, Xue, C.Y. | | Deposit date: | 2023-05-20 | | Release date: | 2024-01-10 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Ligand recognition and G protein coupling of the human itch receptor MRGPRX1.
Nat Commun, 14, 2023
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4UEI
 | | Solution structure of the sterol carrier protein domain 2 of Helicoverpa armigera | | Descriptor: | STEROL CARRIER PROTEIN 2/3-OXOACYL-COA THIOLASE | | Authors: | Liu, X, Ma, H, Yan, X, Hong, H, Peng, J, Peng, R. | | Deposit date: | 2014-12-18 | | Release date: | 2015-12-30 | | Last modified: | 2024-05-15 | | Method: | SOLUTION NMR | | Cite: | NMR Structure and Function of Helicoverpa Armigera Sterol Carrier Protein-2, an Important Insecticidal Target from the Cotton Bollworm.
Sci.Rep., 5, 2015
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4DOY
 | | Crystal structure of Dibenzothiophene desulfurization enzyme C | | Descriptor: | Dibenzothiophene desulfurization enzyme C, GLYCEROL | | Authors: | Liu, S, Zhang, C, Zhu, D, Gu, L. | | Deposit date: | 2012-02-12 | | Release date: | 2013-02-13 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.789 Å) | | Cite: | Crystal structure of DszC from Rhodococcus sp. XP at 1.79 angstrom
Proteins, 82, 2014
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1FVY
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8IBV
 | | Cryo-EM structure of the motilin-bound motilin receptor-Gq protein complex | | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(q) subunit alpha, ... | | Authors: | Jiang, Y, Xu, H.E, You, C, Xu, Y. | | Deposit date: | 2023-02-10 | | Release date: | 2023-04-12 | | Method: | ELECTRON MICROSCOPY (3.19 Å) | | Cite: | Structural basis for motilin and erythromycin recognition by motilin receptor.
Sci Adv, 9, 2023
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8IBU
 | | Cryo-EM structure of the erythromycin-bound motilin receptor-Gq protein complex | | Descriptor: | ERYTHROMYCIN A, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | You, C, Jiang, Y, Xu, H.E, Xu, Y. | | Deposit date: | 2023-02-10 | | Release date: | 2023-04-12 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.51 Å) | | Cite: | Structural basis for motilin and erythromycin recognition by motilin receptor.
Sci Adv, 9, 2023
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6A8O
 | | Crystal structures of the serine protease domain of murine plasma kallikrein with peptide inhibitor mupain-1-16 | | Descriptor: | Plasma kallikrein, alpha-D-mannopyranose, peptide inhibitor,, ... | | Authors: | Xu, M, Jiang, L, Huang, M. | | Deposit date: | 2018-07-09 | | Release date: | 2019-07-10 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.77 Å) | | Cite: | Crystal structure of plasma kallikrein reveals the unusual flexibility of the S1 pocket triggered by Glu217.
Febs Lett., 592, 2018
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6CKU
 | | Solution structure of the zebrafish granulin AaE | | Descriptor: | Granulin-AaE | | Authors: | Wang, P, Ni, F. | | Deposit date: | 2018-02-28 | | Release date: | 2018-06-13 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Structure dissection of zebrafish progranulins identifies a well-folded granulin/epithelin module protein with pro-cell survival activities.
Protein Sci., 27, 2018
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6IRG
 | | Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class II | | Descriptor: | Glutamate receptor ionotropic, NMDA 1, NMDA 2A | | Authors: | Zhang, J, Chang, S, Zhang, X, Zhu, S. | | Deposit date: | 2018-11-12 | | Release date: | 2019-01-16 | | Last modified: | 2019-06-05 | | Method: | ELECTRON MICROSCOPY (5.5 Å) | | Cite: | Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
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6IRA
 | | Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 7.8 | | Descriptor: | Glutamate receptor ionotropic, NMDA 1, NMDA 2A | | Authors: | Zhang, J, Chang, S, Zhang, X, Zhu, S. | | Deposit date: | 2018-11-12 | | Release date: | 2019-01-16 | | Last modified: | 2019-06-05 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
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6VAB
 | | Mouse retromer sub-structure: VPS35/VPS35 flat dimer | | Descriptor: | Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35 | | Authors: | Kendall, A.K, Jackson, L.P. | | Deposit date: | 2019-12-17 | | Release date: | 2020-02-19 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (4.9 Å) | | Cite: | Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes.
Structure, 28, 2020
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6IRF
 | | Structure of the human GluN1/GluN2A NMDA receptor in the glutamate/glycine-bound state at pH 6.3, Class I | | Descriptor: | Glutamate receptor ionotropic, NMDA 1, NMDA 2A | | Authors: | Zhang, J, Chang, S, Zhang, X, Zhu, S. | | Deposit date: | 2018-11-12 | | Release date: | 2019-01-16 | | Last modified: | 2019-06-05 | | Method: | ELECTRON MICROSCOPY (5.1 Å) | | Cite: | Structural Basis of the Proton Sensitivity of Human GluN1-GluN2A NMDA Receptors
Cell Rep, 25, 2018
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6VAC
 | | Mouse retromer (VPS26/VPS35/VPS29) heterotrimer | | Descriptor: | Vacuolar protein sorting-associated protein 26A, Vacuolar protein sorting-associated protein 29, Vacuolar protein sorting-associated protein 35 | | Authors: | Kendall, A.K, Jackson, L.P. | | Deposit date: | 2019-12-17 | | Release date: | 2020-02-19 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (5.7 Å) | | Cite: | Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes.
Structure, 28, 2020
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5ZAT
 | | Crystal structure of 5-carboxylcytosine containing decamer dsDNA | | Descriptor: | DNA (5'-D(*CP*CP*AP*GP*(CAC)P*GP*CP*TP*GP*G)-3') | | Authors: | Fu, T.R, Zhang, L. | | Deposit date: | 2018-02-08 | | Release date: | 2019-02-13 | | Last modified: | 2024-03-27 | | Method: | X-RAY DIFFRACTION (1.06 Å) | | Cite: | Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine.
Chem Sci, 10, 2019
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