8JT8

Crystal structure of 5-HT2AR in complex with (R)-IHCH-7179

Summary for 8JT8

Entry DOI	10.2210/pdb8jt8/pdb
Descriptor	5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, MAGNESIUM ION, 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one, ... (7 entities in total)
Functional Keywords	gpcr, serotonin receptor, antipsychotic, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	1
Total formula weight	46079.44
Authors	Chen, Z.,Fan, L.,Wang, S. (deposition date: 2023-06-21, release date: 2024-02-28, Last modification date: 2024-04-10)
Primary citation	Chen, Z.,Yu, J.,Wang, H.,Xu, P.,Fan, L.,Sun, F.,Huang, S.,Zhang, P.,Huang, H.,Gu, S.,Zhang, B.,Zhou, Y.,Wan, X.,Pei, G.,Xu, H.E.,Cheng, J.,Wang, S. Flexible scaffold-based cheminformatics approach for polypharmacological drug design. Cell, 2024 Cited by PubMed: 38552625 DOI: 10.1016/j.cell.2024.02.034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.7 Å)

Structure validation