8JT8
Crystal structure of 5-HT2AR in complex with (R)-IHCH-7179
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562 | polymer | 376 | 41958.1 | 1 | UniProt (P28223) UniProt (P0ABE7) Pfam (PF00001) Pfam (PF07361) | Homo sapiens (human) | 5-HT-2,5-HT-2A,Serotonin receptor 2A,Cytochrome b-562 |
| 2 | B (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 3 | C (A) | 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one | non-polymer | 377.5 | 1 | Chemie (EZX) | |||
| 4 | D, G, H, I, J... (A) | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate | non-polymer | 356.5 | 7 | Chemie (OLC) | |||
| 5 | E, F (A) | CHOLESTEROL | non-polymer | 386.7 | 2 | Chemie (CLR) | |||
| 6 | K (A) | PENTAETHYLENE GLYCOL | non-polymer | 238.3 | 1 | Chemie (1PE) | |||
| 7 | L, M (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 2 | Chemie (PEG) |
Sequence modifications
A: 70 - 265 (UniProt: P28223)
A: 1001 - 1040 (UniProt: P0ABE7)
A: 1066 - 1106 (UniProt: P0ABE7)
A: 313 - 403 (UniProt: P28223)
| PDB | External Database | Details |
|---|---|---|
| Gly 67 | - | expression tag |
| Gly 68 | - | expression tag |
| Thr 69 | - | expression tag |
| Lys 162 | Ser 162 | engineered mutation |
| Trp 164 | Met 164 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Trp 1007 | Met 29 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Gly 1061 | - | linker |
| Ser 1062 | - | linker |
| Gly 1063 | - | linker |
| Ser 1064 | - | linker |
| Gly 1065 | - | linker |
| Ile 1098 | Arg 120 | engineered mutation |
| Ile 1102 | His 124 | engineered mutation |
| Gly 1106 | Arg 128 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Asn 372 | Ser 372 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 41958.1 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 4121.4 | |
| All* | Total formula weight | 46079.4 |
