6LZL
| Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine | 分子名称: | (2E,4E)-5-(2H-1,3-benzodioxol-5-yl)-1-(piperidin-1-yl)penta-2,4-dien-1-one, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | 著者 | Liu, Z.H, Wu, D, Lu, W.Q, Huang, J. | 登録日 | 2020-02-19 | 公開日 | 2020-04-15 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Crystal structure of human dihydroorotate dehydrogenase (DHODH) with Piperine To Be Published
|
|
6O7X
| Saccharomyces cerevisiae V-ATPase Stv1-V1VO State 3 | 分子名称: | Putative protein YPR170W-B, V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | 著者 | Vasanthakumar, T, Bueler, S.A, Wu, D, Beilsten-Edmands, V, Robinson, C.V, Rubinstein, J.L. | 登録日 | 2019-03-08 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (8.7 Å) | 主引用文献 | Structural comparison of the vacuolar and Golgi V-ATPases fromSaccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
|
|
6O7U
| Saccharomyces cerevisiae V-ATPase Stv1-VO | 分子名称: | Putative protein YPR170W-B, V-type proton ATPase subunit a, Golgi isoform, ... | 著者 | Vasanthakumar, T, Bueler, S.A, Wu, D, Beilsten-Edmands, V, Robinson, C.V, Rubinstein, J.L. | 登録日 | 2019-03-08 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural comparison of the vacuolar and Golgi V-ATPases fromSaccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
|
|
6O7T
| Saccharomyces cerevisiae V-ATPase Vph1-VO | 分子名称: | Putative protein YPR170W-B, V-type proton ATPase subunit a, vacuolar isoform, ... | 著者 | Vasanthakumar, T, Bueler, S.A, Wu, D, Beilsten-Edmands, V, Robinson, C.V, Rubinstein, J.L. | 登録日 | 2019-03-08 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural comparison of the vacuolar and Golgi V-ATPases fromSaccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
|
|
6O7V
| Saccharomyces cerevisiae V-ATPase Stv1-V1VO State 1 | 分子名称: | Putative protein YPR170W-B, V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | 著者 | Vasanthakumar, T, Bueler, S.A, Wu, D, Beilsten-Edmands, V, Robinson, C.V, Rubinstein, J.L. | 登録日 | 2019-03-08 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (6.6 Å) | 主引用文献 | Structural comparison of the vacuolar and Golgi V-ATPases fromSaccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
|
|
6O7W
| Saccharomyces cerevisiae V-ATPase Stv1-V1VO State 2 | 分子名称: | Putative protein YPR170W-B, V-type proton ATPase subunit B, V-type proton ATPase subunit C, ... | 著者 | Vasanthakumar, T, Bueler, S.A, Wu, D, Beilsten-Edmands, V, Robinson, C.V, Rubinstein, J.L. | 登録日 | 2019-03-08 | 公開日 | 2019-04-03 | 最終更新日 | 2024-03-20 | 実験手法 | ELECTRON MICROSCOPY (7 Å) | 主引用文献 | Structural comparison of the vacuolar and Golgi V-ATPases fromSaccharomyces cerevisiae. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
|
|
7XYO
| Crystal Structure of a M61 aminopeptidase family member from Myxococcus fulvus | 分子名称: | Aminopeptidase M61, HEXAETHYLENE GLYCOL, TETRAETHYLENE GLYCOL, ... | 著者 | Chen, X, Wang, X, Huo, L, Wu, D. | 登録日 | 2022-06-02 | 公開日 | 2023-06-07 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery and Characterization of a Myxobacterial Lanthipeptide with Unique Biosynthetic Features and Anti-inflammatory Activity. J.Am.Chem.Soc., 145, 2023
|
|
7YHN
| ANTI-TUMOR AGENT Y48 IN COMPLEX WITH TUBULIN | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-methyl-3-[(4-methylphenyl)sulfonylamino]-~{N}-[(6-methylpyridin-3-yl)methyl]benzamide, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Du, T, Ji, M, Hou, Z, Lin, S, Zhang, J, Wu, D, Zhang, K, Lu, D, Xu, H, Chen, X. | 登録日 | 2022-07-14 | 公開日 | 2023-07-26 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site. J.Med.Chem., 65, 2022
|
|
4PW8
| Human tryptophan 2,3-dioxygenase | 分子名称: | COBALT (II) ION, Tryptophan 2,3-dioxygenase | 著者 | Meng, B, Wu, D, Gu, J.H, Ouyang, S.Y, Ding, W, Liu, Z.J. | 登録日 | 2014-03-19 | 公開日 | 2014-08-06 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.902 Å) | 主引用文献 | Structural and functional analyses of human tryptophan 2,3-dioxygenase Proteins, 82, 2014
|
|
4RHW
| Crystal structure of Apaf-1 CARD and caspase-9 CARD complex | 分子名称: | Apoptotic protease-activating factor 1, CHLORIDE ION, Caspase-9, ... | 著者 | Hu, Q, Wu, D, Yan, C, Shi, Y. | 登録日 | 2014-10-03 | 公開日 | 2014-10-15 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Molecular determinants of caspase-9 activation by the Apaf-1 apoptosome. Proc. Natl. Acad. Sci. U.S.A., 111, 2014
|
|
7W80
| Crystal Structure of the Heterodimeric HIF-2 in Complex with Antagonist Belzutifan | 分子名称: | 3-{[(1S,2S,3R)-2,3-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1 | 著者 | Ren, X, Diao, X, Zhuang, J, Wu, D. | 登録日 | 2021-12-07 | 公開日 | 2022-09-21 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.754 Å) | 主引用文献 | Structural basis for the allosteric inhibition of hypoxia-inducible factor (HIF)-2 by belzutifan. Mol.Pharmacol., 2022
|
|
7V7L
| Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex | 分子名称: | Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 3-alpha | 著者 | Diao, X, Ren, X, Li, F.W, Sun, X, Wu, D. | 登録日 | 2021-08-21 | 公開日 | 2022-05-18 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha. Nat Commun, 13, 2022
|
|
7V7W
| Crystal Structure of the Heterodimeric HIF-3a:ARNT Complex with oleoylethanolamide (OEA) | 分子名称: | (Z)-N-(2-hydroxyethyl)octadec-9-enamide, Aryl hydrocarbon receptor nuclear translocator, Hypoxia-inducible factor 3-alpha | 著者 | Diao, X, Ren, X, Li, F.W, Zhang, M, Sun, X, Wu, D. | 登録日 | 2021-08-21 | 公開日 | 2022-05-18 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.507 Å) | 主引用文献 | Identification of oleoylethanolamide as an endogenous ligand for HIF-3 alpha. Nat Commun, 13, 2022
|
|
5UAN
| Crystal structure of multi-domain RAR-beta-RXR-alpha heterodimer on DNA | 分子名称: | (9cis)-retinoic acid, DNA (5'-D(*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*G)-3'), ... | 著者 | Chandra, V, Wu, D, Kim, Y, Rastinejad, F. | 登録日 | 2016-12-19 | 公開日 | 2017-10-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.508 Å) | 主引用文献 | The quaternary architecture of RAR beta-RXR alpha heterodimer facilitates domain-domain signal transmission. Nat Commun, 8, 2017
|
|
5X07
| Crystal structure of FOXA2 DNA binding domain bound to a full consensus DNA site | 分子名称: | DNA (5'-D(*CP*AP*AP*AP*AP*TP*GP*TP*AP*AP*AP*CP*AP*AP*GP*A)-3'), DNA (5'-D(*TP*CP*TP*TP*GP*TP*TP*TP*AP*CP*AP*TP*TP*TP*TP*G)-3'), Hepatocyte nuclear factor 3-beta | 著者 | Li, J, Guo, M, Zhou, Z, Jiang, L, Chen, X, Qu, L, Wu, D, Chen, Z, Chen, L, Chen, Y. | 登録日 | 2017-01-20 | 公開日 | 2017-08-16 | 最終更新日 | 2017-09-27 | 実験手法 | X-RAY DIFFRACTION (2.796 Å) | 主引用文献 | Structure of the Forkhead Domain of FOXA2 Bound to a Complete DNA Consensus Site Biochemistry, 56, 2017
|
|
4N0A
| Crystal structure of Lsm2-3-Pat1C complex from Saccharomyces cerevisiae | 分子名称: | DNA topoisomerase 2-associated protein PAT1, U6 snRNA-associated Sm-like protein LSm2, U6 snRNA-associated Sm-like protein LSm3 | 著者 | Wu, D.H. | 登録日 | 2013-10-01 | 公開日 | 2013-12-04 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | Lsm2 and Lsm3 bridge the interaction of the Lsm1-7 complex with Pat1 for decapping activation Cell Res., 24, 2014
|
|
8EW7
| Human Serum Albumin with Cobalt (II) and Myristic Acid - crystal 2 | 分子名称: | COBALT (II) ION, MYRISTIC ACID, Serum albumin | 著者 | Gucwa, M, Cooper, D.R, Stewart, A.J, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID) | 登録日 | 2022-10-21 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Human Serum Albumin with Cobalt (II) and Myristic Acid To Be Published
|
|
8EW4
| Human Serum Albumin with Cobalt (II) and Myristic Acid - crystal 1 | 分子名称: | COBALT (II) ION, MYRISTIC ACID, Serum albumin | 著者 | Gucwa, M, Cooper, D.R, Unciano, J, Lea, K, Kim, L, Lenkiewicz, J, Starban, I, Stewart, A.J, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID) | 登録日 | 2022-10-21 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Human Serum Albumin with Cobalt (II) and Myristic Acid To Be Published
|
|
8EY5
| Human Serum Albumin with Cobalt (II) and Myristic Acid - crystal 3 | 分子名称: | COBALT (II) ION, MYRISTIC ACID, Serum albumin | 著者 | Gucwa, M, Cooper, D.R, Stewart, A.J, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID), Center for Structural Biology of Infectious Diseases (CSBID) | 登録日 | 2022-10-26 | 公開日 | 2022-11-09 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Human Serum Albumin with Cobalt (II) and Myristic Acid To Be Published
|
|
7YLA
| Cryo-EM structure of 50S-HflX complex | 分子名称: | 50S ribosomal protein L11, 50S ribosomal protein L13, 50S ribosomal protein L14, ... | 著者 | Damu, W, Ning, G. | 登録日 | 2022-07-25 | 公開日 | 2023-01-04 | 最終更新日 | 2024-01-17 | 実験手法 | ELECTRON MICROSCOPY (2.52 Å) | 主引用文献 | Cryo-EM Structure of the 50S-HflX Complex Reveals a Novel Mechanism of Antibiotic Resistance in E. coli Biorxiv, 2022
|
|
8YJY
| |
7YW0
| Bacteroides fragilis Hcp5 | 分子名称: | Bacterodales T6SS protein TssD (Hcp) | 著者 | Wen, Y, He, W, Bai, Y. | 登録日 | 2022-08-20 | 公開日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Structure and assembly of type VI secretion system cargo delivery vehicle. Cell Rep, 42, 2023
|
|
6Z45
| CDK9-Cyclin-T1 complex bound by compound 24 | 分子名称: | (1~{S},3~{R})-3-acetamido-~{N}-[5-chloranyl-4-(5,5-dimethyl-4,6-dihydropyrrolo[1,2-b]pyrazol-3-yl)pyridin-2-yl]cyclohexane-1-carboxamide, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Cyclin-T1, ... | 著者 | Ferguson, A, Collie, G.W. | 登録日 | 2020-05-22 | 公開日 | 2020-12-23 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (3.37 Å) | 主引用文献 | Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies. J.Med.Chem., 63, 2020
|
|
7QVL
| OESTROGEN RECEPTOR LIGAND BINDING DOMAIN IN COMPLEX WITH COMPOUND 38 | 分子名称: | (2~{R})-3-[(1~{R},3~{R})-1-[5-fluoranyl-2-[2-(3-fluoranylpropylamino)ethoxy]-3-methyl-pyridin-4-yl]-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]-2-methyl-propanoic acid, Estrogen receptor | 著者 | Breed, J. | 登録日 | 2022-01-21 | 公開日 | 2023-02-01 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists. J.Med.Chem., 66, 2023
|
|
7QVJ
| ESTROGEN RECEPTOR ALPHA IN COMPLEX WITH COMPOUND 29 | 分子名称: | 2,2-bis(fluoranyl)-3-[(1~{R},3~{R})-1-[6-fluoranyl-3-[2-(3-fluoranylpropylamino)ethoxy]-2-methyl-phenyl]-3-methyl-1,3,4,9-tetrahydropyrido[3,4-b]indol-2-yl]propan-1-ol, Estrogen receptor | 著者 | Breed, J. | 登録日 | 2022-01-21 | 公開日 | 2023-02-01 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.68 Å) | 主引用文献 | Discovery of a Potent and Orally Bioavailable Zwitterionic Series of Selective Estrogen Receptor Degrader-Antagonists. J.Med.Chem., 66, 2023
|
|