7YHN

ANTI-TUMOR AGENT Y48 IN COMPLEX WITH TUBULIN

Summary for 7YHN

• Entry DOI: 10.2210/pdb7yhn/pdb
• Related: 6LS4
• Descriptor: Tubulin alpha-1B chain, Tubulin beta chain, Stathmin, ... (9 entities in total)
• Functional Keywords: mitosis, antitumor protein, structural protein
• Biological source: Sus scrofa (pig); More
• Total number of polymer chains: 5
• Total formula weight: 221641.89

Authors

Du, T.,Ji, M.,Hou, Z.,Lin, S.,Zhang, J.,Wu, D.,Zhang, K.,Lu, D.,Xu, H.,Chen, X. (deposition date: 2022-07-14, release date: 2023-07-26, Last modification date: 2024-02-07)

• Primary citation: Lin, S.,Du, T.,Zhang, J.,Wu, D.,Tian, H.,Zhang, K.,Jiang, L.,Lu, D.,Sheng, L.,Li, Y.,Ji, M.,Chen, X.,Xu, H.; Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site.; J.Med.Chem., 65:16372-16391, 2022; PubMed: 36511661; DOI: 10.1021/acs.jmedchem.2c01208

Experimental method

X-RAY DIFFRACTION (2.6 Å)