6LS4
A novel anti-tumor agent S-40 in complex with tubulin
Summary for 6LS4
Entry DOI | 10.2210/pdb6ls4/pdb |
Descriptor | Tubulin alpha-1B chain, Tubulin beta chain, Stathmin, ... (10 entities in total) |
Functional Keywords | mitosis, antitumor protein, structural protein |
Biological source | Sus scrofa (Pig) More |
Total number of polymer chains | 5 |
Total formula weight | 221758.00 |
Authors | |
Primary citation | Du, T.,Lin, S.,Ji, M.,Xue, N.,Liu, Y.,Zhang, Z.,Zhang, K.,Zhang, J.,Zhang, Y.,Wang, Q.,Sheng, L.,Li, Y.,Lu, D.,Chen, X.,Xu, H. A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity. Cancer Lett., 495:22-32, 2020 Cited by PubMed: 32931884DOI: 10.1016/j.canlet.2020.08.040 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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