7YHN
ANTI-TUMOR AGENT Y48 IN COMPLEX WITH TUBULIN
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Tubulin alpha-1B chain | polymer | 451 | 50204.4 | 2 | UniProt (Q2XVP4) Pfam (PF00091) Pfam (PF03953) | Sus scrofa (pig) | Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain |
| 2 | B, D (B, D) | Tubulin beta chain | polymer | 445 | 49999.9 | 2 | UniProt (P02554) Pfam (PF00091) Pfam (PF03953) | Sus scrofa (pig) | Beta-tubulin |
| 3 | E (E) | Stathmin | polymer | 152 | 18060.4 | 1 | UniProt (F2Z508) Pfam (PF00836) | Sus scrofa (pig) | |
| 4 | F, M, P (A, C, D) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 3 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 5 | G, H, L, N, O... (A, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 6 | Chemie (MG) PubChem (888) | |||
| 6 | I (B) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 7 | J (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) PubChem (4478249) | |||
| 8 | K, R (B, D) | 4-methyl-3-[(4-methylphenyl)sulfonylamino]-~{N}-[(6-methylpyridin-3-yl)methyl]benzamide | non-polymer | 409.5 | 2 | Chemie (IUK) PubChem (139369407) | |||
| 9 | S, T, U, V (A, B, C, D) | water | water | 18.0 | 22 | Chemie (HOH) |
Sequence modifications
B, D: 1 - 445 (UniProt: P02554)
E: 2 - 142 (UniProt: F2Z508)
| PDB | External Database | Details |
|---|---|---|
| Thr 55 | Ala 55 | conflict |
| Met 170 | Val 170 | conflict |
| Ser 296 | Ala 296 | conflict |
| Ile 316 | Val 316 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 1 | - | expression tag |
| Leu 143 | - | expression tag |
| Glu 144 | - | expression tag |
| His 145 | - | expression tag |
| His 146 | - | expression tag |
| His 147 | - | expression tag |
| His 148 | - | expression tag |
| His 149 | - | expression tag |
| His 150 | - | expression tag |
| His 151 | - | expression tag |
| His 152 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 218469.1 | |
| Non-Polymers* | Number of molecules | 13 |
| Total formula weight | 3172.8 | |
| All* | Total formula weight | 221641.9 |
