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2H2C
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BU of 2h2c by Molmil
Crystal Structure of ZO-1 PDZ1 Bound to a Phage-Derived Ligand (WRRTTWV)
Descriptor: Tight junction protein ZO-1
Authors:Appleton, B.A, Zhang, Y, Wu, P, Yin, J.P, Hunziker, W, Skelton, N.J, Sidhu, S.S, Wiesmann, C.
Deposit date:2006-05-18
Release date:2006-06-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
2H2B
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BU of 2h2b by Molmil
Crystal Structure of ZO-1 PDZ1 Bound to a Phage-Derived Ligand (WRRTTYL)
Descriptor: ACETIC ACID, Tight junction protein ZO-1
Authors:Appleton, B.A, Zhang, Y, Wu, P, Yin, J.P, Hunziker, W, Skelton, N.J, Sidhu, S.S, Wiesmann, C.
Deposit date:2006-05-18
Release date:2006-06-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
2H3M
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BU of 2h3m by Molmil
Crystal Structure of ZO-1 PDZ1
Descriptor: SULFATE ION, Tight junction protein ZO-1
Authors:Appleton, B.A, Zhang, Y, Wu, P, Yin, J.P, Hunziker, W, Skelton, N.J, Sidhu, S.S, Wiesmann, C.
Deposit date:2006-05-22
Release date:2006-06-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Comparative structural analysis of the Erbin PDZ domain and the first PDZ domain of ZO-1. Insights into determinants of PDZ domain specificity.
J.Biol.Chem., 281, 2006
1QSV
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BU of 1qsv by Molmil
THE VEGF-BINDING DOMAIN OF FLT-1, 20 NMR STRUCTURES
Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1
Authors:Starovasnik, M.A, Christinger, H.W, Wiesmann, C, Champe, M.A, de Vos, A.M, Skelton, N.J.
Deposit date:1999-06-23
Release date:1999-11-10
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.
J.Mol.Biol., 293, 1999
1QSZ
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BU of 1qsz by Molmil
THE VEGF-BINDING DOMAIN OF FLT-1 (MINIMIZED MEAN)
Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 1
Authors:Starovasnik, M.A, Christinger, H.W, Wiesmann, C, Champe, M.A, de Vos, A.M, Skelton, N.J.
Deposit date:1999-06-24
Release date:1999-11-10
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of the VEGF-binding domain of Flt-1: comparison of its free and bound states.
J.Mol.Biol., 293, 1999
3BE1
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BU of 3be1 by Molmil
Dual specific bH1 Fab in complex with the extracellular domain of HER2/ErbB-2
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab Fragment-Heavy Chain, ...
Authors:Bostrom, J.M, Wiesmann, C, Appleton, B.A.
Deposit date:2007-11-15
Release date:2008-11-18
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site
Science, 323, 2009
3B9V
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BU of 3b9v by Molmil
Crystal Structure of an Autonomous VH Domain
Descriptor: heavy chain variable domain
Authors:Appleton, B.A, Barthelemy, P.A, Wiesmann, C.
Deposit date:2007-11-06
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Comprehensive Analysis of the Factors Contributing to the Stability and Solubility of Autonomous Human VH Domains.
J.Biol.Chem., 283, 2008
3CC0
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BU of 3cc0 by Molmil
The Dvl2 PDZ Domain in Complex with the N3 Inhibitory Peptide
Descriptor: Dishevelled-2
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2008-02-23
Release date:2009-03-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Inhibition of Wnt signaling by Dishevelled PDZ peptides
Nat.Chem.Biol., 5, 2009
3CBX
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BU of 3cbx by Molmil
The Dvl2 PDZ Domain in Complex with the C1 Inhibitory Peptide
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Dishevelled-2
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2008-02-23
Release date:2009-03-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inhibition of Wnt signaling by Dishevelled PDZ peptides
Nat.Chem.Biol., 5, 2009
3CBY
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BU of 3cby by Molmil
The Dvl2 PDZ Domain in Complex with the N1 Inhibitory Peptide
Descriptor: 1,2-ETHANEDIOL, Dishevelled-2
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2008-02-23
Release date:2009-03-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Inhibition of Wnt signaling by Dishevelled PDZ peptides
Nat.Chem.Biol., 5, 2009
3CBZ
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BU of 3cbz by Molmil
The Dvl2 PDZ Domain in Complex with the N2 Inhibitory Peptide
Descriptor: 1,2-ETHANEDIOL, Dishevelled-2, PHOSPHATE ION
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2008-02-23
Release date:2009-03-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.38 Å)
Cite:Inhibition of Wnt signaling by Dishevelled PDZ peptides
Nat.Chem.Biol., 5, 2009
3E4C
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BU of 3e4c by Molmil
Procaspase-1 zymogen domain crystal structure
Descriptor: Caspase-1, MAGNESIUM ION
Authors:Elliott, J.M, Rouge, L, Wiesmann, C, Scheer, J.M.
Deposit date:2008-08-11
Release date:2008-12-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of procaspase-1 zymogen domain reveals insight into inflammatory caspase autoactivation
J.Biol.Chem., 284, 2009
6THP
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BU of 6thp by Molmil
Neprilysin in complex with the inhibitor (R)-4-(1-carboxy-3-(3'-chlorobiphenyl-4-yl)propan-2-ylamino)-4-oxobutanoic acid
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[[(2~{R})-1-[4-(3-chlorophenyl)phenyl]-4-oxidanyl-4-oxidanylidene-butan-2-yl]amino]-4-oxidanylidene-butanoic acid, Neprilysin, ...
Authors:Schiering, N, Wiesmann, C.
Deposit date:2019-11-21
Release date:2020-02-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors.
Acs Med.Chem.Lett., 11, 2020
1SHM
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BU of 1shm by Molmil
Convergent solutions to VHH domain stabilization from natural and in vitro evolution
Descriptor: ANTIBODY RIG
Authors:Bond, C.J, Wiesmann, C, Marsters, J.C, Sidhu, S.S.
Deposit date:2004-02-26
Release date:2005-03-08
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A structure-based database of antibody variable domain diversity.
J.Mol.Biol., 348, 2005
1WWC
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BU of 1wwc by Molmil
NT3 BINDING DOMAIN OF HUMAN TRKC RECEPTOR
Descriptor: PROTEIN (NT-3 GROWTH FACTOR RECEPTOR TRKC)
Authors:Ultsch, M.H, Wiesmann, C, Simmons, L.C, Henrich, J, Yang, M, Reilly, D, Bass, S.H, De Vos, A.M.
Deposit date:1999-04-30
Release date:1999-07-07
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC.
J.Mol.Biol., 290, 1999
2P3W
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BU of 2p3w by Molmil
Crystal Structure of the HtrA3 PDZ Domain Bound to a Phage-Derived Ligand (FGRWV)
Descriptor: Probable serine protease HTRA3
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2007-03-09
Release date:2007-11-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and functional analysis of the PDZ domains of human HtrA1 and HtrA3.
Protein Sci., 16, 2007
2PZD
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BU of 2pzd by Molmil
Crystal Structure of the HtrA2/Omi PDZ Domain Bound to a Phage-Derived Ligand (WTMFWV)
Descriptor: 1,2-ETHANEDIOL, Serine protease HTRA2
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2007-05-17
Release date:2007-08-07
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural and functional analysis of the ligand specificity of the HtrA2/Omi PDZ domain.
Protein Sci., 16, 2007
2QQO
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BU of 2qqo by Molmil
Crystal Structure of the a2b1b2 Domains from Human Neuropilin-2
Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CALCIUM ION, ...
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2007-07-26
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQN
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BU of 2qqn by Molmil
Neuropilin-1 b1 Domain in Complex with a VEGF-Blocking Fab
Descriptor: 1,2-ETHANEDIOL, Antibody heavy chain, Antibody light chain, ...
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2007-07-26
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQM
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BU of 2qqm by Molmil
Crystal Structure of the a2b1b2 Domains from Human Neuropilin-1
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2007-07-26
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQK
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BU of 2qqk by Molmil
Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Antibody Heavy Chain, Antibody Light Chain, ...
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2007-07-26
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQI
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BU of 2qqi by Molmil
Crystal Structure of the b1b2 Domains from Human Neuropilin-1
Descriptor: GLYCEROL, Neuropilin-1
Authors:Appleton, B.A, Desmarais, W, Wiesmann, C.
Deposit date:2007-07-26
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQL
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BU of 2qql by Molmil
Neuropilin-2 a1a2b1b2 Domains in Complex with a Semaphorin-Blocking Fab
Descriptor: Antibody Heavy Chain, Antibody Light Chain, Neuropilin-2
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2007-07-26
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
2QQJ
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BU of 2qqj by Molmil
Crystal Structure of the b1b2 Domains from Human Neuropilin-2
Descriptor: GLYCEROL, Neuropilin-2
Authors:Appleton, B.A, Wiesmann, C.
Deposit date:2007-07-26
Release date:2007-11-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural studies of neuropilin/antibody complexes provide insights into semaphorin and VEGF binding
Embo J., 26, 2007
3S1B
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BU of 3s1b by Molmil
The Development of Peptide-based Tools for the Analysis of Angiogenesis
Descriptor: Vascular endothelial growth factor A, mini-Z
Authors:Murray, J.M, Wiesmann, C.
Deposit date:2011-05-14
Release date:2011-08-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The development of Peptide-based tools for the analysis of angiogenesis.
Chem.Biol., 18, 2011

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