6THP
Neprilysin in complex with the inhibitor (R)-4-(1-carboxy-3-(3'-chlorobiphenyl-4-yl)propan-2-ylamino)-4-oxobutanoic acid
Summary for 6THP
Entry DOI | 10.2210/pdb6thp/pdb |
Descriptor | Neprilysin, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION, ... (5 entities in total) |
Functional Keywords | inhibitor, complex, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 161731.16 |
Authors | Schiering, N.,Wiesmann, C. (deposition date: 2019-11-21, release date: 2020-02-12, Last modification date: 2024-01-24) |
Primary citation | Kawanami, T.,Karki, R.G.,Cody, E.,Liu, Q.,Liang, G.,Ksander, G.M.,Rigel, D.F.,Schiering, N.,Gong, Y.,Coppola, G.M.,Iwaki, Y.,Sun, R.,Neubert, A.,Fan, L.,Ingles, S.,D'Arcy, A.,Villard, F.,Ramage, P.,Jeng, A.Y.,Leung-Chu, J.,Liu, J.,Beil, M.,Fu, F.,Chen, W.,Cumin, F.,Wiesmann, C.,Mogi, M. Structure-Guided Design of Substituted Biphenyl Butanoic Acid Derivatives as Neprilysin Inhibitors. Acs Med.Chem.Lett., 11:188-194, 2020 Cited by PubMed: 32071687DOI: 10.1021/acsmedchemlett.9b00578 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.54 Å) |
Structure validation
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