6THP

Neprilysin in complex with the inhibitor (R)-4-(1-carboxy-3-(3'-chlorobiphenyl-4-yl)propan-2-ylamino)-4-oxobutanoic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Neprilysin	polymer	696	79525.5	2	UniProt (P08473) Pfam (PF05649) Pfam (PF01431)	Homo sapiens (Human)	Atriopeptidase,Common acute lymphocytic leukemia antigen,CALLA,Enkephalinase,Neutral endopeptidase 24.11,Neutral endopeptidase,Skin fibroblast elastase,SFE
2	C, D, E, F, I... (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	8	Chemie (NAG)
3	G, M (A, B)	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
4	H, N (A, B)	4-[[(2~{R})-1-[4-(3-chlorophenyl)phenyl]-4-oxidanyl-4-oxidanylidene-butan-2-yl]amino]-4-oxidanylidene-butanoic acid	non-polymer		389.8	2	Chemie (N9Q)
5	O, P (A, B)	water	water		18.0	352	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	159051.0
Non-Polymers*	Number of molecules	12
	Total formula weight	2680.1
All*	Total formula weight	161731.2

*Water molecules are not included.