5Z6Y
 
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7KFU
 | | Cas6-RT-Cas1--Cas2 complex | | 分子名称: | Cas2, Cas6-RT-Cas1 | | 著者 | Hoel, C.M, Wang, J.Y, Doudna, J.A, Brohawn, S.G. | | 登録日 | 2020-10-14 | | 公開日 | 2021-03-31 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex.
Nat Commun, 12, 2021
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7KFT
 | | Partial Cas6-RT-Cas1--Cas2 complex | | 分子名称: | Cas2, Cas6-RT-Cas1 | | 著者 | Hoel, C.M, Wang, J.Y, Doudna, J.A, Brohawn, S.G. | | 登録日 | 2020-10-14 | | 公開日 | 2021-03-31 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural coordination between active sites of a CRISPR reverse transcriptase-integrase complex.
Nat Commun, 12, 2021
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6XF4
 | | Crystal structure of STING REF variant in complex with E7766 | | 分子名称: | (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-difluoro-34,39-disulfanyl-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34,39-diphosphaoctacyclo[28.6.4.1~3,36~.1~28,31~.0~4,8~.0~7,12~.0~19,24~.0~23,27~]dotetraconta-5,7,9,11,15,19,21,23,25-nonaene 34,39-dioxide (non-preferred name), 1,2-ETHANEDIOL, Stimulator of interferon genes protein | | 著者 | Chen, Y, Wang, J.Y, Kim, D.-S. | | 登録日 | 2020-06-15 | | 公開日 | 2021-02-17 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | | 主引用文献 | E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity.
Chemmedchem, 16, 2021
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6XF3
 | | Crystal structure of STING in complex with E7766 | | 分子名称: | (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-difluoro-34,39-disulfanyl-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34,39-diphosphaoctacyclo[28.6.4.1~3,36~.1~28,31~.0~4,8~.0~7,12~.0~19,24~.0~23,27~]dotetraconta-5,7,9,11,15,19,21,23,25-nonaene 34,39-dioxide (non-preferred name), Stimulator of interferon genes protein | | 著者 | Chen, Y, Wang, J.Y, Kim, D.-S. | | 登録日 | 2020-06-15 | | 公開日 | 2021-02-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.38 Å) | | 主引用文献 | E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity.
Chemmedchem, 16, 2021
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8W8S
 | | Cryo-EM structure of the AA14-bound GPR101 complex | | 分子名称: | 1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea, Probable G-protein coupled receptor 101 | | 著者 | Sun, J.P, Yu, X, Gao, N, Yang, F, Wang, J.Y, Yang, Z, Guan, Y, Wang, G.P. | | 登録日 | 2023-09-04 | | 公開日 | 2024-01-03 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of GPR101-Gs enables identification of ligands with rejuvenating potential.
Nat.Chem.Biol., 20, 2024
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8W8Q
 | | Cryo-EM structure of the GPR101-Gs complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | | 著者 | Sun, J.P, Gao, N, Yu, X, Wang, G.P, Yang, F, Wang, J.Y, Yang, Z, Guan, Y. | | 登録日 | 2023-09-04 | | 公開日 | 2024-01-03 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (2.89 Å) | | 主引用文献 | Structure of GPR101-Gs enables identification of ligands with rejuvenating potential.
Nat.Chem.Biol., 20, 2024
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8W8R
 | | Cryo-EM structure of the AA-14-bound GPR101-Gs complex | | 分子名称: | 1-(4-methylpyridin-2-yl)-3-[3-(trifluoromethyl)phenyl]thiourea, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Sun, J.P, Yu, X, Gao, N, Yang, F, Wang, J.Y, Yang, Z, Guan, Y, Wang, G.P. | | 登録日 | 2023-09-04 | | 公開日 | 2024-01-03 | | 最終更新日 | 2024-04-10 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structure of GPR101-Gs enables identification of ligands with rejuvenating potential.
Nat.Chem.Biol., 20, 2024
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8HOC
 | | Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex | | 分子名称: | 2-(1~{H}-imidazol-5-yl)ethyl carbamimidothioate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Tang, W.Q, Sun, X.Y, Li, F.H, Wang, J.Y. | | 登録日 | 2022-12-09 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure insights into Histamine H4 receptor activation by an endogenous ligand histamine and agonist imetit
To Be Published
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8HN8
 | | Cryo-EM structure of ligand histamine-bound Histamine H4 receptor Gi complex | | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | | 著者 | Tang, W.Q, Sun, X.Y, Li, F.H, Wang, J.Y. | | 登録日 | 2022-12-07 | | 公開日 | 2023-12-20 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structure insights into Histamine H4 receptor activation by an endogenous ligand histamine and agonist imetit
To Be Published
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7C5C
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7WWW
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1K6Y
 | | Crystal Structure of a Two-Domain Fragment of HIV-1 Integrase | | 分子名称: | Integrase, PHOSPHATE ION, POTASSIUM ION, ... | | 著者 | Wang, J, Ling, H, Yang, W, Craigie, R. | | 登録日 | 2001-10-17 | | 公開日 | 2001-12-21 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein.
EMBO J., 20, 2001
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8FYA
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-containing prespacer complex | | 分子名称: | Cas1, Cas2-DEDDh, DNA (28-MER), ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (2.91 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FYD
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex bent CRISPR repeat conformation | | 分子名称: | Cas1, Cas2-DEDDh, DNA (13-MER), ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FY9
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-deficient prespacer complex | | 分子名称: | Cas1, Cas2-DEDDh, DNA (28-MER) | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FYC
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex linear CRISPR repeat conformation | | 分子名称: | Cas1, Cas2-DEDDh, DEDDh, ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FYB
 | | Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex | | 分子名称: | Cas1, Cas2-DEDDh, DNA (17-MER), ... | | 著者 | Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J. | | 登録日 | 2023-01-25 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-07-05 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
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8FBI
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8FBJ
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8FBN
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8FBO
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8FBK
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7CKH
 | | Crystal structure of TMSiPheRS | | 分子名称: | Tyrosine--tRNA ligase | | 著者 | Sun, J.P, Wang, J.Y, Zhu, Z.L, He, Q.T, Xiao, P. | | 登録日 | 2020-07-17 | | 公開日 | 2021-03-31 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.79492676 Å) | | 主引用文献 | DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1 H-NMR probe.
Nat Commun, 11, 2020
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7CKG
 | | Crystal structure of TMSiPheRS complexed with TMSiPhe | | 分子名称: | 4-(trimethylsilyl)-L-phenylalanine, Tyrosine--tRNA ligase | | 著者 | Sun, J.P, Wang, J.Y, Zhu, Z.L, He, Q.T, Xiao, P. | | 登録日 | 2020-07-17 | | 公開日 | 2021-03-31 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.053 Å) | | 主引用文献 | DeSiphering receptor core-induced and ligand-dependent conformational changes in arrestin via genetic encoded trimethylsilyl 1 H-NMR probe.
Nat Commun, 11, 2020
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