6XF3

Crystal structure of STING in complex with E7766

Summary for 6XF3

• Entry DOI: 10.2210/pdb6xf3/pdb
• Descriptor: Stimulator of interferon genes protein, (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-difluoro-34,39-disulfanyl-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34,39-diphosphaoctacyclo[28.6.4.1~3,36~.1~28,31~.0~4,8~.0~7,12~.0~19,24~.0~23,27~]dotetraconta-5,7,9,11,15,19,21,23,25-nonaene 34,39-dioxide (non-preferred name) (3 entities in total)
• Functional Keywords: stimulator of interferon genes (sting), e7766, agonist, macrocycle, immune system
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 43947.11

Authors

Chen, Y.,Wang, J.Y.,Kim, D.-S. (deposition date: 2020-06-15, release date: 2021-02-17, Last modification date: 2023-10-18)

• Primary citation: Kim, D.S.,Endo, A.,Fang, F.G.,Huang, K.C.,Bao, X.,Choi, H.W.,Majumder, U.,Shen, Y.Y.,Mathieu, S.,Zhu, X.,Sanders, K.,Noland, T.,Hao, M.H.,Chen, Y.,Wang, J.Y.,Yasui, S.,TenDyke, K.,Wu, J.,Ingersoll, C.,Loiacono, K.A.,Hutz, J.E.,Sarwar, N.; E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity.; Chemmedchem, 16:1740-1743, 2021; PubMed: 33522135; DOI: 10.1002/cmdc.202100068

Experimental method

X-RAY DIFFRACTION (2.38 Å)