6XF3
Crystal structure of STING in complex with E7766
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Stimulator of interferon genes protein | polymer | 189 | 21600.3 | 2 | UniProt (Q86WV6) Pfam (PF15009) | Homo sapiens (Human) | hSTING,Endoplasmic reticulum interferon stimulator,ERIS,Mediator of IRF3 activation,hMITA,Transmembrane protein 173 |
| 2 | C (A) | (1R,3R,15E,28R,29R,30R,31R,34R,36R,39S,41R)-29,41-difluoro-34,39-disulfanyl-2,33,35,38,40,42-hexaoxa-4,6,9,11,13,18,20,22,25,27-decaaza-34,39-diphosphaoctacyclo[28.6.4.1~3,36~.1~28,31~.0~4,8~.0~7,12~.0~19,24~.0~23,27~]dotetraconta-5,7,9,11,15,19,21,23,25-nonaene 34,39-dioxide (non-preferred name) | non-polymer | 746.6 | 1 | Chemie (V5V) | |||
| 3 | D, E (A, B) | water | water | 18.0 | 130 | Chemie (HOH) |
Sequence modifications
A, B: 155 - 341 (UniProt: Q86WV6)
| PDB | External Database | Details |
|---|---|---|
| Gly 153 | - | expression tag |
| Ser 154 | - | expression tag |
| Arg 232 | His 232 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 43200.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 746.6 | |
| All* | Total formula weight | 43947.1 |
