3PLT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3plt by Molmil](/molmil-images/mine/3plt) | |
7RSL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rsl by Molmil](/molmil-images/mine/7rsl) | Seipin forms a flexible cage at lipid droplet formation sites | Descriptor: | Seipin | Authors: | Arlt, H, Sui, X, Folger, B, Adams, C, Chen, X, Remme, R, Hamprecht, F.A, DiMaio, F, Liao, M, Goodman, J.M, Farese Jr, R.V, Walther, T.C. | Deposit date: | 2021-08-11 | Release date: | 2022-02-09 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | Seipin forms a flexible cage at lipid droplet formation sites. Nat.Struct.Mol.Biol., 29, 2022
|
|
8ERC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8erc by Molmil](/molmil-images/mine/8erc) | |
6MLU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6mlu by Molmil](/molmil-images/mine/6mlu) | Cryo-EM structure of lipid droplet formation protein Seipin/BSCL2 | Descriptor: | Seipin | Authors: | Sui, X, Arlt, H, Liao, M, Walther, C.T, Farese, V.R. | Deposit date: | 2018-09-28 | Release date: | 2018-10-17 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Cryo-electron microscopy structure of the lipid droplet-formation protein seipin. J. Cell Biol., 217, 2018
|
|
6VYI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6vyi by Molmil](/molmil-images/mine/6vyi) | Cryo-EM structure of human diacylglycerol O-acyltransferase 1 | Descriptor: | Diacylglycerol O-acyltransferase 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Sui, X, Wang, K, Gluchowski, N, Liao, M, Walther, C.T, Farese, V.R. | Deposit date: | 2020-02-26 | Release date: | 2020-05-13 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature, 581, 2020
|
|
6VZ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6vz1 by Molmil](/molmil-images/mine/6vz1) | Cryo-EM structure of human diacylglycerol O-acyltransferase 1 complexed with acyl-CoA substrate | Descriptor: | Diacylglycerol O-acyltransferase 1, S-{(3R,5R,9R)-1-[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-4-hydroxy-3-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} (9Z)-octadec-9-enethioate (non-preferred name), [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | Authors: | Sui, X, Wang, K, Gluchowski, N, Liao, M, Walther, C.T, Farese Jr, V.R. | Deposit date: | 2020-02-27 | Release date: | 2020-05-13 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme. Nature, 581, 2020
|
|
8ESM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8esm by Molmil](/molmil-images/mine/8esm) | Human triacylglycerol synthesizing enzyme DGAT1 in complex with T863 inhibitor | Descriptor: | Diacylglycerol O-acyltransferase 1, {(1r,4r)-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl}acetic acid | Authors: | Sui, X, Kun, W, Walther, T, Farese, R, Liao, M. | Deposit date: | 2022-10-14 | Release date: | 2023-06-07 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis. Nat Commun, 14, 2023
|
|
5DSE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5dse by Molmil](/molmil-images/mine/5dse) | Crystal Structure of the TTC7B/Hyccin Complex | Descriptor: | Hyccin, Tetratricopeptide repeat protein 7B | Authors: | Wu, X, Baskin, J.M, Reinisch, K.M, De Camilli, P. | Deposit date: | 2015-09-17 | Release date: | 2015-12-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Nat.Cell Biol., 18, 2016
|
|
8ETM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8etm by Molmil](/molmil-images/mine/8etm) | Human triacylglycerol synthesizing enzyme DGAT1 in complex with DGAT1IN1 inhibitor | Descriptor: | Diacylglycerol O-acyltransferase 1, [(1S,4r)-4-{4-[(4S)-2-({[4-(trifluoromethoxy)phenyl]methyl}carbamoyl)imidazo[1,2-a]pyridin-6-yl]phenyl}cyclohexyl]acetic acid | Authors: | Sui, X, Kun, W, Walther, T, Farese, R, Liao, M. | Deposit date: | 2022-10-17 | Release date: | 2023-06-07 | Last modified: | 2024-06-19 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis. Nat Commun, 14, 2023
|
|