3J42
| Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody | 分子名称: | Envelope protein E, Ig heavy chain V region MOPC 21, Igh protein chimera, ... | 著者 | Wang, Z, Pennington, J.G, Jiang, W, Rossmann, M.G. | 登録日 | 2013-06-13 | 公開日 | 2013-07-17 | 最終更新日 | 2018-07-18 | 実験手法 | ELECTRON MICROSCOPY (21 Å) | 主引用文献 | Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody. J.Virol., 87, 2013
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1QNE
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3KCF
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3LKJ
| Small Molecule Inhibition of the TNF Family Cyokine CD40 Ligand Through a Subunit Fracture Mechanism | 分子名称: | (2R)-{[(2'-[(biphenyl-3-ylmethyl)carbamoyl]-6'-{[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-6-{[(2R)-2-(1H-pyrrol-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-4,4'-bipyridin-2-yl)carbonyl]amino}(cyclohexyl)ethanoic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CD40 ligand | 著者 | Silvian, L.F, Whitty, A. | 登録日 | 2010-01-27 | 公開日 | 2011-02-02 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism. Acs Chem.Biol., 6, 2011
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4KVC
| 2H2 Fab fragment of immature Dengue virus | 分子名称: | Ig heavy chain V region MOPC 21, Igh protein, Ig kappa chain V-V region MOPC 21, ... | 著者 | Wang, Z, Rossmann, M.G. | 登録日 | 2013-05-22 | 公開日 | 2013-07-24 | 最終更新日 | 2017-08-02 | 実験手法 | X-RAY DIFFRACTION (2.306 Å) | 主引用文献 | Obstruction of Dengue Virus Maturation by Fab Fragments of the 2H2 Antibody. J.Virol., 87, 2013
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7S4S
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6VWU
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3I6D
| Crystal structure of PPO from bacillus subtilis with AF | 分子名称: | 5-[2-CHLORO-4-(TRIFLUOROMETHYL)PHENOXY]-2-NITROBENZOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, PHOSPHATE ION, ... | 著者 | Shen, Y. | 登録日 | 2009-07-06 | 公開日 | 2009-12-08 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structural insight into unique properties of protoporphyrinogen oxidase from Bacillus subtilis J.Struct.Biol., 170, 2010
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5Y3X
| Crystal structure of endo-1,4-beta-xylanase from Caldicellulosiruptor owensensis | 分子名称: | Beta-xylanase | 著者 | Liu, X, Sun, L.C, Zhang, Y.B, Liu, T.F, Xin, F.J. | 登録日 | 2017-07-31 | 公開日 | 2017-12-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structural Insights into the Thermophilic Adaption Mechanism of Endo-1,4-beta-Xylanase from Caldicellulosiruptor owensensis. J. Agric. Food Chem., 66, 2018
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5I2K
| Structure of the human GluN1/GluN2A LBD in complex with 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide (compound 19) | 分子名称: | 7-{[ethyl(4-fluorophenyl)amino]methyl}-N,2-dimethyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide, GLUTAMIC ACID, GLYCINE, ... | 著者 | Wallweber, H.J.A, Lupardus, P.J. | 登録日 | 2016-02-09 | 公開日 | 2016-03-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design. J.Med.Chem., 59, 2016
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5I2N
| Structure of the human GluN1/GluN2A LBD in complex with N-ethyl-7-{[2-fluoro-3-(trifluoromethyl)phenyl]methyl}-2-methyl-5-oxo-5H-[1,3]thiazolo[3,2-a]pyrimidine-3-carboxamide (compound 29) | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, GLUTAMIC ACID, ... | 著者 | Wallweber, H.J.A, Lupardus, P.J. | 登録日 | 2016-02-09 | 公開日 | 2016-03-16 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | 主引用文献 | Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design. J.Med.Chem., 59, 2016
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5I9E
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5Y4L
| PRRSV nsp4 | 分子名称: | Non-structural protein | 著者 | Shi, Y.J, Gang, Y, Peng, G.Q. | 登録日 | 2017-08-04 | 公開日 | 2018-01-17 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.198 Å) | 主引用文献 | Identification of two antiviral inhibitors targeting 3C-like serine/3C-like protease of porcine reproductive and respiratory syndrome virus and porcine epidemic diarrhea virus. Vet. Microbiol., 213, 2018
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6LKX
| The structure of PRRSV helicase | 分子名称: | CITRIC ACID, GLYCEROL, RNA-dependent RNA polymerase, ... | 著者 | Shi, Y.J, Tong, X.H, Peng, G.Q. | 登録日 | 2019-12-20 | 公開日 | 2020-05-27 | 最終更新日 | 2021-06-09 | 実験手法 | X-RAY DIFFRACTION (2.998 Å) | 主引用文献 | Structural Characterization of the Helicase nsp10 Encoded by Porcine Reproductive and Respiratory Syndrome Virus. J.Virol., 94, 2020
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7DWC
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7XHO
| Structure of human inner kinetochore CCAN complex | 分子名称: | CENP-W, Centromere protein C, Centromere protein H, ... | 著者 | Tian, T, Wang, C.L, Yang, Z.S, Sun, L.F, Zang, J.Y. | 登録日 | 2022-04-09 | 公開日 | 2022-12-14 | 最終更新日 | 2023-01-25 | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | 主引用文献 | Structural insights into human CCAN complex assembled onto DNA. Cell Discov, 8, 2022
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7XHN
| Structure of human inner kinetochore CCAN-DNA complex | 分子名称: | CENP-W, Centromere protein C, Centromere protein H, ... | 著者 | Sun, L.F, Tian, T, Wang, C.L, Yang, Z.S, Zang, J.Y. | 登録日 | 2022-04-09 | 公開日 | 2023-01-25 | 実験手法 | ELECTRON MICROSCOPY (3.71 Å) | 主引用文献 | Structural insights into human CCAN complex assembled onto DNA. Cell Discov, 8, 2022
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2I47
| Crystal structure of catalytic domain of TACE with inhibitor | 分子名称: | 4-({[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}METHYL)-1-[(3,5-DIMETHYLISOXAZOL-4-YL)SULFONYL]-N-HYDROXYPIPERIDINE-4-CARBOXAMIDE, ADAM 17, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... | 著者 | Xu, W, Condon, J.S, Lovering, F.E. | 登録日 | 2006-08-21 | 公開日 | 2006-12-05 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Identification of potent and selective TACE inhibitors via the S1 pocket. Bioorg.Med.Chem.Lett., 17, 2007
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7DLY
| Crystal structure of Arabidopsis ACS7 mutant in complex with PPG | 分子名称: | (2E,3E)-4-(2-aminoethoxy)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid, 1-aminocyclopropane-1-carboxylate synthase 7 | 著者 | Hao, B, Zhang, Y, Li, X, Rao, Z. | 登録日 | 2020-11-30 | 公開日 | 2021-09-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | 主引用文献 | Dual activities of ACC synthase: Novel clues regarding the molecular evolution of ACS genes. Sci Adv, 7, 2021
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7DLW
| Crystal structure of Arabidopsis ACS7 in complex with PPG | 分子名称: | (2E,3E)-4-(2-aminoethoxy)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]but-3-enoic acid, 1-aminocyclopropane-1-carboxylate synthase 7, SULFATE ION | 著者 | Hao, B, Zhang, Y, Li, X, Rao, Z. | 登録日 | 2020-11-30 | 公開日 | 2021-09-29 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Dual activities of ACC synthase: Novel clues regarding the molecular evolution of ACS genes. Sci Adv, 7, 2021
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4Z8M
| Crystal structure of the MAVS-TRAF6 complex | 分子名称: | Peptide from Mitochondrial antiviral-signaling protein, TNF receptor-associated factor 6 | 著者 | Shi, Z.B, Zhou, Z. | 登録日 | 2015-04-09 | 公開日 | 2015-09-23 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Structural Insights into Mitochondrial Antiviral Signaling Protein (MAVS)-Tumor Necrosis Factor Receptor-associated Factor 6 (TRAF6) Signaling J.Biol.Chem., 290, 2015
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5W6M
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8GQU
| AK-42 inhibitor binding human ClC-2 TMD | 分子名称: | 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, Chloride channel protein 2 | 著者 | Wang, L. | 登録日 | 2022-08-30 | 公開日 | 2023-07-05 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42. Nat Commun, 14, 2023
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4O67
| Human cyclic GMP-AMP synthase (cGAS) in complex with GAMP | 分子名称: | Cyclic GMP-AMP synthase, ZINC ION, cGAMP | 著者 | Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J. | 登録日 | 2013-12-20 | 公開日 | 2014-02-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.444 Å) | 主引用文献 | The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop. Cell Rep, 6, 2014
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4O68
| Structure of human cyclic GMP-AMP synthase (cGAS) | 分子名称: | Cyclic GMP-AMP synthase, ZINC ION | 著者 | Zhang, X, Chen, Z, Zhang, X.W, Chen, Z.J. | 登録日 | 2013-12-20 | 公開日 | 2014-02-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.436 Å) | 主引用文献 | The Cytosolic DNA Sensor cGAS Forms an Oligomeric Complex with DNA and Undergoes Switch-like Conformational Changes in the Activation Loop. Cell Rep, 6, 2014
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