2I47
Crystal structure of catalytic domain of TACE with inhibitor
Summary for 2I47
Entry DOI | 10.2210/pdb2i47/pdb |
Related | 1BKC 2A8H |
Related PRD ID | PRD_000919 |
Descriptor | ADAM 17, ZINC ION, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... (5 entities in total) |
Functional Keywords | tace/adam-17, tace-inhibitor complex, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P78536 |
Total number of polymer chains | 4 |
Total formula weight | 132497.36 |
Authors | Xu, W.,Condon, J.S.,Lovering, F.E. (deposition date: 2006-08-21, release date: 2006-12-05, Last modification date: 2021-10-20) |
Primary citation | Condon, J.S.,Joseph-McCarthy, D.,Levin, J.I.,Lombart, H.G.,Lovering, F.E.,Sun, L.,Wang, W.,Xu, W.,Zhang, Y. Identification of potent and selective TACE inhibitors via the S1 pocket. Bioorg.Med.Chem.Lett., 17:34-39, 2007 Cited by PubMed: 17064892DOI: 10.1016/j.bmcl.2006.10.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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