2A8H
Crystal structure of catalytic domain of TACE with Thiomorpholine Sulfonamide Hydroxamate inhibitor
Summary for 2A8H
Entry DOI | 10.2210/pdb2a8h/pdb |
Related | 1bkc 1ZXC |
Descriptor | ADAM 17, ZINC ION, 4-({4-[(4-AMINOBUT-2-YNYL)OXY]PHENYL}SULFONYL)-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE, ... (4 entities in total) |
Functional Keywords | tace/adam-17, tace-inhibitor complex, zn-endopeptidase, hydrolase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P78536 |
Total number of polymer chains | 2 |
Total formula weight | 62378.53 |
Authors | Levin, J.I.,Chen, J.M.,Laakso, L.M.,Du, M.,Schmid, J.,Xu, W.,Cummons, T.,Xu, J.,Jin, G.,Barone, D.,Skotnicki, J.S. (deposition date: 2005-07-08, release date: 2006-02-07, Last modification date: 2023-08-23) |
Primary citation | Levin, J.I.,Chen, J.M.,Laakso, L.M.,Du, M.,Schmid, J.,Xu, W.,Cummons, T.,Xu, J.,Jin, G.,Barone, D.,Skotnicki, J.S. Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates. Bioorg.Med.Chem.Lett., 16:1605-1609, 2006 Cited by PubMed: 16426848DOI: 10.1016/j.bmcl.2005.12.020 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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