2A8H

Crystal structure of catalytic domain of TACE with Thiomorpholine Sulfonamide Hydroxamate inhibitor

Summary for 2A8H

Entry DOI	10.2210/pdb2a8h/pdb
Related	1ZXC 1bkc
Descriptor	ADAM 17, ZINC ION, 4-({4-[(4-AMINOBUT-2-YNYL)OXY]PHENYL}SULFONYL)-N-HYDROXY-2,2-DIMETHYLTHIOMORPHOLINE-3-CARBOXAMIDE, ... (4 entities in total)
Functional Keywords	tace/adam-17, tace-inhibitor complex, zn-endopeptidase, hydrolase
Biological source	Homo sapiens (human)
Cellular location	Membrane; Single-pass type I membrane protein: P78536
Total number of polymer chains	2
Total formula weight	62378.53
Authors	Levin, J.I.,Chen, J.M.,Laakso, L.M.,Du, M.,Schmid, J.,Xu, W.,Cummons, T.,Xu, J.,Jin, G.,Barone, D.,Skotnicki, J.S. (deposition date: 2005-07-08, release date: 2006-02-07, Last modification date: 2023-08-23)
Primary citation	Levin, J.I.,Chen, J.M.,Laakso, L.M.,Du, M.,Schmid, J.,Xu, W.,Cummons, T.,Xu, J.,Jin, G.,Barone, D.,Skotnicki, J.S. Acetylenic TACE inhibitors. Part 3: Thiomorpholine sulfonamide hydroxamates. Bioorg.Med.Chem.Lett., 16:1605-1609, 2006 Cited by PubMed: 16426848 DOI: 10.1016/j.bmcl.2005.12.020 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation