1BKC

CATALYTIC DOMAIN OF TNF-ALPHA CONVERTING ENZYME (TACE)

Summary for 1BKC

• Entry DOI: 10.2210/pdb1bkc/pdb
• Related PRD ID: PRD_000919
• Descriptor: TUMOR NECROSIS FACTOR-ALPHA-CONVERTING ENZYME, ZINC ION, N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide, ... (6 entities in total)
• Functional Keywords: zn-endopeptidase, hydrolase, tnf-alpha
• Biological source: Homo sapiens (human); More
• Cellular location: Membrane; Single-pass type I membrane protein: P78536 P78536 P78536
• Total number of polymer chains: 4
• Total formula weight: 117771.63

Authors

Maskos, K.,Fernandez-Catalan, C.,Bode, W. (deposition date: 1998-04-23, release date: 1999-06-22, Last modification date: 2021-11-03)

• Primary citation: Maskos, K.,Fernandez-Catalan, C.,Huber, R.,Bourenkov, G.P.,Bartunik, H.,Ellestad, G.A.,Reddy, P.,Wolfson, M.F.,Rauch, C.T.,Castner, B.J.,Davis, R.,Clarke, H.R.,Petersen, M.,Fitzner, J.N.,Cerretti, D.P.,March, C.J.,Paxton, R.J.,Black, R.A.,Bode, W.; Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme.; Proc.Natl.Acad.Sci.USA, 95:3408-3412, 1998; PubMed: 9520379; DOI: 10.1073/pnas.95.7.3408

Experimental method

X-RAY DIFFRACTION (2 Å)