1BKC

CATALYTIC DOMAIN OF TNF-ALPHA CONVERTING ENZYME (TACE)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0006508	biological_process	proteolysis
A	0008237	molecular_function	metallopeptidase activity
C	0004222	molecular_function	metalloendopeptidase activity
C	0006508	biological_process	proteolysis
C	0008237	molecular_function	metallopeptidase activity
E	0004222	molecular_function	metalloendopeptidase activity
E	0006508	biological_process	proteolysis
E	0008237	molecular_function	metallopeptidase activity
I	0004222	molecular_function	metalloendopeptidase activity
I	0006508	biological_process	proteolysis
I	0008237	molecular_function	metallopeptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1

Chain	Residue
A	INN2
A	HIS405
A	HIS409
A	HIS415

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1

Chain	Residue
C	INN2
C	HIS405
C	HIS409
C	HIS415

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN E 1

Chain	Residue
E	HIS405
E	HIS409
E	HIS415
E	INN2

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN I 1

Chain	Residue
I	INN2
I	HIS405
I	HIS409
I	HIS415

---

site_id	AC5
Number of Residues	18
Details	BINDING SITE FOR RESIDUE INN A 2

Chain	Residue
A	ZN1
A	MET345
A	GLY346
A	THR347
A	LEU348
A	GLY349
A	TYR390
A	HIS405
A	GLU406
A	HIS409
A	HIS415
A	TYR436
A	PRO437
A	ILE438
A	ALA439
A	HOH586
A	HOH601
A	HOH605

---

site_id	AC6
Number of Residues	18
Details	BINDING SITE FOR RESIDUE INN C 2

Chain	Residue
C	ZN1
C	MET345
C	GLY346
C	THR347
C	LEU348
C	GLY349
C	ASN389
C	HIS405
C	GLU406
C	HIS409
C	HIS415
C	PRO437
C	ILE438
C	ALA439
C	HOH622
C	HOH787
C	HOH798
C	HOH880

---

site_id	AC7
Number of Residues	20
Details	BINDING SITE FOR RESIDUE INN E 2

Chain	Residue
E	ZN1
E	MET345
E	GLY346
E	THR347
E	LEU348
E	GLY349
E	LEU350
E	ASN389
E	HIS405
E	GLU406
E	HIS409
E	HIS415
E	PRO437
E	ILE438
E	ALA439
E	HOH643
E	HOH683
E	HOH690
E	HOH810
E	HOH813

---

site_id	AC8
Number of Residues	16
Details	BINDING SITE FOR RESIDUE INN I 2

Chain	Residue
I	ZN1
I	MET345
I	GLY346
I	THR347
I	LEU348
I	GLY349
I	ASN389
I	TYR390
I	HIS405
I	GLU406
I	HIS409
I	HIS415
I	TYR436
I	PRO437
I	ILE438
I	ALA439

---

Functional Information from PROSITE/UniProt

site_id	PS00142
Number of Residues	10
Details	ZINC_PROTEASE Neutral zinc metallopeptidases, zinc-binding region signature. VTTHELGHNF

Chain	Residue	Details
I	VAL402-PHE411
E	VAL402-PHE411
A	VAL402-PHE411

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"},{"source":"PROSITE-ProRule","id":"PRU10095","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"9520379","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PubMed","id":"9520379","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	8
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	753
Details	Domain: {"description":"Peptidase M12B","evidences":[{"source":"PROSITE-ProRule","id":"PRU00276","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---