1BKC

CATALYTIC DOMAIN OF TNF-ALPHA CONVERTING ENZYME (TACE)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	TUMOR NECROSIS FACTOR-ALPHA-CONVERTING ENZYME	polymer	256	28954.5	2	UniProt (P78536) Pfam (PF13688) In PDB	Homo sapiens (human)	TACE
2	E	TUMOR NECROSIS FACTOR-ALPHA-CONVERTING ENZYME	polymer	256	28970.5	1	UniProt (P78536) Pfam (PF13688) In PDB	Homo sapiens (human)	TACE
3	I	TUMOR NECROSIS FACTOR-ALPHA-CONVERTING ENZYME	polymer	256	28968.5	1	UniProt (P78536) Pfam (PF13688) In PDB	Homo sapiens (human)	TACE
4	A, C, E, I	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
5	A, C, E, I	N-{(2R)-2-[2-(hydroxyamino)-2-oxoethyl]-4-methylpentanoyl}-3-methyl-L-valyl-N-(2-aminoethyl)-L-alaninamide	non-polymer		415.5	4	BIRD (PRD_000919) Chemie (INN)
6		water	water		18.0	1620	Chemie (HOH)

Sequence modifications

A, C: 219 - 474 (UniProt: P78536)

PDB	External Database	Details
Ala 266	Ser 266	engineered mutation
Gln 452	Asn 452	engineered mutation

E: 219 - 474 (UniProt: P78536)

PDB	External Database	Details
Ala 266	Ser 266	engineered mutation
Lys 420	Leu 420	conflict
Gln 452	Asn 452	engineered mutation

I: 219 - 474 (UniProt: P78536)

PDB	External Database	Details
Ala 266	Ser 266	engineered mutation
Glu 428	Asp 428	conflict
Gln 452	Asn 452	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	115847.9
Non-Polymers*	Number of molecules	8
	Total formula weight	1923.7
All*	Total formula weight	117771.6

*Water molecules are not included.