8GQU
AK-42 inhibitor binding human ClC-2 TMD
Summary for 8GQU
Entry DOI | 10.2210/pdb8gqu/pdb |
EMDB information | 34202 |
Descriptor | Chloride channel protein 2, 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid (2 entities in total) |
Functional Keywords | homo-dimer, membrane protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 198063.17 |
Authors | Wang, L. (deposition date: 2022-08-30, release date: 2023-07-05, Last modification date: 2024-05-08) |
Primary citation | Ma, T.,Wang, L.,Chai, A.,Liu, C.,Cui, W.,Yuan, S.,Wing Ngor Au, S.,Sun, L.,Zhang, X.,Zhang, Z.,Lu, J.,Gao, Y.,Wang, P.,Li, Z.,Liang, Y.,Vogel, H.,Wang, Y.T.,Wang, D.,Yan, K.,Zhang, H. Cryo-EM structures of ClC-2 chloride channel reveal the blocking mechanism of its specific inhibitor AK-42. Nat Commun, 14:3424-3424, 2023 Cited by PubMed: 37296152DOI: 10.1038/s41467-023-39218-6 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.5 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)