7D4B
| Crystal structure of 4-1BB in complex with a VHH | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Wang, C. | Deposit date: | 2020-09-23 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.14 Å) | Cite: | Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer. J Immunother Cancer, 9, 2021
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7CZD
| Crystal structure of PD-L1 in complex with a VHH | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Programmed cell death 1 ligand 1, ... | Authors: | Wang, C. | Deposit date: | 2020-09-08 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Generation of a safe and efficacious llama single-domain antibody fragment (vHH) targeting the membrane-proximal region of 4-1BB for engineering therapeutic bispecific antibodies for cancer. J Immunother Cancer, 9, 2021
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7F5A
| DNQX-bound GluK2-2xNeto2 complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, kainate 2, ... | Authors: | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | Deposit date: | 2021-06-21 | Release date: | 2021-09-29 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (6.4 Å) | Cite: | Kainate receptor modulation by NETO2. Nature, 599, 2021
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7F56
| DNQX-bound GluK2-1xNeto2 complex, with asymmetric LBD | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, kainate 2, ... | Authors: | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | Deposit date: | 2021-06-21 | Release date: | 2021-09-29 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Kainate receptor modulation by NETO2. Nature, 599, 2021
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7F59
| DNQX-bound GluK2-1xNeto2 complex | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | Authors: | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | Deposit date: | 2021-06-21 | Release date: | 2021-09-29 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Kainate receptor modulation by NETO2. Nature, 599, 2021
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7F57
| Kainate-bound GluK2-1xNeto2 complex, at the desensitized state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, kainate 2, ... | Authors: | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | Deposit date: | 2021-06-21 | Release date: | 2021-09-29 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Kainate receptor modulation by NETO2. Nature, 599, 2021
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7F5B
| LBD-TMD focused reconstruction of DNQX-bound GluK2-1xNeto2 complex | Descriptor: | (1S)-2-{[{[(2R)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | He, L.L, Gao, Y.W, Li, B, Zhao, Y. | Deposit date: | 2021-06-21 | Release date: | 2021-09-29 | Last modified: | 2021-12-01 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Kainate receptor modulation by NETO2. Nature, 599, 2021
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5Z30
| The crystal structure of the nucleosome containing a cancer-associated histone H2A.Z R80C mutant | Descriptor: | CHLORIDE ION, DNA (146-MER), Histone H2A.Z, ... | Authors: | Horikoshi, N, Arimura, Y, Kurumizaka, H. | Deposit date: | 2018-01-05 | Release date: | 2018-07-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome. Nucleic Acids Res., 46, 2018
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5UJ8
| Human Origin Recognition Complex subunits 2 and 3 | Descriptor: | Origin recognition complex subunit 2, Origin recognition complex subunit 3 | Authors: | Tocilj, A, On, K.F, Elkayam, E, Joshua-Tor, L. | Deposit date: | 2017-01-17 | Release date: | 2017-02-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (6 Å) | Cite: | Structure of the active form of human Origin Recognition Complex and its ATPase motor module. Elife, 6, 2017
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5UJ7
| Structure of the active form of human Origin Recognition Complex ATPase motor module, complex subunitS 1, 4, 5 | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Origin recognition complex subunit 1, ... | Authors: | Tocilj, A, Elkayam, E, On, K.F, Joshua-Tor, L. | Deposit date: | 2017-01-17 | Release date: | 2017-02-08 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.394 Å) | Cite: | Structure of the active form of human Origin Recognition Complex and its ATPase motor module. Elife, 6, 2017
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5W6V
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1I2H
| CRYSTAL STRUCTURE ANALYSIS OF PSD-ZIP45(HOMER1C/VESL-1L)CONSERVED HOMER 1 DOMAIN | Descriptor: | PSD-ZIP45(HOMER-1C/VESL-1L) | Authors: | Irie, K, Nakatsu, T, Mitsuoka, K, Fujiyoshi, Y, Kato, H. | Deposit date: | 2001-02-09 | Release date: | 2002-05-29 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of the Homer 1 Family Conserved Region Reveals the Interaction Between the EVH1 Domain and
Own Proline-rich Motif J.Mol.Biol., 318, 2002
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6JKV
| PppA, a key regulatory component of T6SS in Pseudomonas aeruginosa | Descriptor: | MANGANESE (II) ION, PppA | Authors: | Wang, T, Liu, L, Wu, Y, Li, D. | Deposit date: | 2019-03-02 | Release date: | 2019-06-26 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of PppA from Pseudomonas aeruginosa, a key regulatory component of type VI secretion systems. Biochem.Biophys.Res.Commun., 516, 2019
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4OJN
| Crystal structure of human muscle L-lactate dehydrogenase | Descriptor: | GLYCEROL, L-lactate dehydrogenase A chain, PENTAETHYLENE GLYCOL | Authors: | Kolappan, S, Craig, L. | Deposit date: | 2014-01-21 | Release date: | 2014-12-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. Acta Crystallogr.,Sect.D, 71, 2015
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6M4C
| C. albicans actin interacting protein Aip5 | Descriptor: | C. albicans actin interacting protein Aip5 | Authors: | Loh, Z.Y, Gao, Y.G, Xie, Y, Miao, Y. | Deposit date: | 2020-03-06 | Release date: | 2020-08-26 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Orchestrated actin nucleation by the Candida albicans polarisome complex enables filamentous growth. J.Biol.Chem., 295, 2020
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4OKN
| Crystal structure of human muscle L-lactate dehydrogenase, ternary complex with NADH and oxalate | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, KANAMYCIN A, L-lactate dehydrogenase A chain, ... | Authors: | Kolappan, S, Craig, L. | Deposit date: | 2014-01-22 | Release date: | 2014-12-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structures of lactate dehydrogenase A (LDHA) in apo, ternary and inhibitor-bound forms. Acta Crystallogr.,Sect.D, 71, 2015
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6LPI
| Crystal Structure of AHAS holo-enzyme | Descriptor: | Acetolactate synthase isozyme 1 large subunit, Acetolactate synthase isozyme 1 small subunit, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Zhang, Y, Yang, X, Xi, Z, Shen, Y. | Deposit date: | 2020-01-10 | Release date: | 2020-11-18 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.849 Å) | Cite: | Molecular architecture of the acetohydroxyacid synthase holoenzyme. Biochem.J., 477, 2020
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7X98
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7YSU
| Cryo-EM Structure of FGF23-FGFR3c-aKlotho-HS Quaternary Complex | Descriptor: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, COPPER (II) ION, Fibroblast growth factor 23, ... | Authors: | Mohammadi, M, Chen, L. | Deposit date: | 2022-08-13 | Release date: | 2023-04-19 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis for FGF hormone signalling. Nature, 618, 2023
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7YSH
| Cryo-EM Structure of FGF23-FGFR1c-aKlotho-HS Quaternary Complex | Descriptor: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, COPPER (II) ION, Fibroblast growth factor 23, ... | Authors: | Mohammadi, M, Chen, L. | Deposit date: | 2022-08-12 | Release date: | 2023-04-19 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (2.74 Å) | Cite: | Structural basis for FGF hormone signalling. Nature, 618, 2023
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7YSW
| Cryo-EM Structure of FGF23-FGFR4-aKlotho-HS Quaternary Complex | Descriptor: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, COPPER (II) ION, Fibroblast growth factor 23, ... | Authors: | Mohammadi, M, Chen, L. | Deposit date: | 2022-08-13 | Release date: | 2023-06-14 | Last modified: | 2023-07-05 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Structural basis for FGF hormone signalling. Nature, 618, 2023
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5XF0
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5Y0C
| Crystal Structure of the human nucleosome at 2.09 angstrom resolution | Descriptor: | CHLORIDE ION, DNA (146-MER), Histone H2A type 1-B/E, ... | Authors: | Kurumizaka, H, Arimura, Y, Fujita, R, Noda, M. | Deposit date: | 2017-07-16 | Release date: | 2018-07-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.087 Å) | Cite: | Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome. Nucleic Acids Res., 46, 2018
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5Y0D
| Crystal Structure of the human nucleosome containing the H2B E76K mutant | Descriptor: | CHLORIDE ION, DNA (146-MER), Histone H2A type 1-B/E, ... | Authors: | Kurumizaka, H, Arimura, Y, Fujita, R, Noda, M. | Deposit date: | 2017-07-16 | Release date: | 2018-07-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Cancer-associated mutations of histones H2B, H3.1 and H2A.Z.1 affect the structure and stability of the nucleosome. Nucleic Acids Res., 46, 2018
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7XTQ
| Cryo-EM structure of the R399-bound GPBAR-Gs complex | Descriptor: | G-protein coupled bile acid receptor 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Ma, L, Yang, F, Wu, X, Mao, C, Sun, J, Yu, X, Zhang, Y, Zhang, P. | Deposit date: | 2022-05-17 | Release date: | 2022-07-06 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural basis and molecular mechanism of biased GPBAR signaling in regulating NSCLC cell growth via YAP activity. Proc.Natl.Acad.Sci.USA, 119, 2022
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