7KPG
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![BU of 7kpg by Molmil](/molmil-images/mine/7kpg) | Blocking Fab 25 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 | Descriptor: | Heavy chain of Fab 25 anti-SIRP-alpha antibody, Light chain of Fab 25 anti-SIRP-alpha antibody, SULFATE ION, ... | Authors: | Sim, J, Pons, J. | Deposit date: | 2020-11-11 | Release date: | 2020-12-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Targeting the myeloid checkpoint receptor SIRP alpha potentiates innate and adaptive immune responses to promote anti-tumor activity. J Hematol Oncol, 13, 2020
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5D1Z
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![BU of 5d1z by Molmil](/molmil-images/mine/5d1z) | IsdB NEAT1 bound by clone D4-10 | Descriptor: | D4-10 Heavy Chain, D4-10 Light Chain, Iron-regulated surface determinant protein B, ... | Authors: | Deng, X. | Deposit date: | 2015-08-04 | Release date: | 2016-09-14 | Last modified: | 2016-12-07 | Method: | X-RAY DIFFRACTION (3.17 Å) | Cite: | Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire. Nat Commun, 7, 2016
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5D1Q
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![BU of 5d1q by Molmil](/molmil-images/mine/5d1q) | IsdB NEAT2 bound by clone D2-06 | Descriptor: | D2-06 Heavy Chain, D2-06 Light Chain, Iron-regulated surface determinant protein B, ... | Authors: | Deng, X. | Deposit date: | 2015-08-04 | Release date: | 2016-08-10 | Last modified: | 2016-12-07 | Method: | X-RAY DIFFRACTION (3.22 Å) | Cite: | Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire. Nat Commun, 7, 2016
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4IDJ
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![BU of 4idj by Molmil](/molmil-images/mine/4idj) | S.Aureus a-hemolysin monomer in complex with Fab | Descriptor: | Alpha-hemolysin, Fab Heavy chain, Fab Light chain, ... | Authors: | Strop, P. | Deposit date: | 2012-12-12 | Release date: | 2013-06-26 | Last modified: | 2021-05-26 | Method: | X-RAY DIFFRACTION (3.36 Å) | Cite: | Mechanism of Action and In Vivo Efficacy of a Human-Derived Antibody against Staphylococcus aureus alpha-Hemolysin. J.Mol.Biol., 425, 2013
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6UUP
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![BU of 6uup by Molmil](/molmil-images/mine/6uup) | Structure of anti-hCD33 conditional scFv | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Anti-CD33 conditional scFv, DI(HYDROXYETHYL)ETHER, ... | Authors: | Kimberlin, C.R, Park, S. | Deposit date: | 2019-10-31 | Release date: | 2020-11-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.20001864 Å) | Cite: | Direct control of CAR T cells through small molecule-regulated antibodies. Nat Commun, 12, 2021
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6UY3
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![BU of 6uy3 by Molmil](/molmil-images/mine/6uy3) | |
6NMV
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![BU of 6nmv by Molmil](/molmil-images/mine/6nmv) | Non-Blocking Fab 218 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 | Descriptor: | Fab 218 anti-SIRP-alpha antibody Variable Heavy Chain, Fab 218 anti-SIRP-alpha antibody Variable Light Chain, Tyrosine-protein phosphatase non-receptor type substrate 1 | Authors: | Wibowo, A.S, Carter, J.J, Sim, J. | Deposit date: | 2019-01-11 | Release date: | 2019-08-07 | Last modified: | 2019-08-14 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRP alpha. Mabs, 11, 2019
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6NMR
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![BU of 6nmr by Molmil](/molmil-images/mine/6nmr) | Blocking Fab 119 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 | Descriptor: | Fab 119 anti-SIRP-alpha antibody Variable Heavy Chain, Fab 119 anti-SIRP-alpha antibody Variable Light Chain, Tyrosine-protein phosphatase non-receptor type substrate 1 | Authors: | Wibowo, A.S, Carter, J.J, Sim, J. | Deposit date: | 2019-01-11 | Release date: | 2019-08-07 | Last modified: | 2019-08-14 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRP alpha. Mabs, 11, 2019
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6NMT
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![BU of 6nmt by Molmil](/molmil-images/mine/6nmt) | Non-Blocking Fab 3 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 | Descriptor: | Fab 3 anti-SIRP-alpha antibody Variable Heavy Chain, Fab 3 anti-SIRP-alpha antibody Variable Light Chain, Tyrosine-protein phosphatase non-receptor type substrate 1 | Authors: | Wibowo, A.S, Carter, J.J, Sim, J. | Deposit date: | 2019-01-11 | Release date: | 2019-08-07 | Last modified: | 2019-08-14 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRP alpha. Mabs, 11, 2019
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6NMS
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![BU of 6nms by Molmil](/molmil-images/mine/6nms) | Blocking Fab 136 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 | Descriptor: | Fab 136 anti-SIRP-alpha antibody Variable Heavy Chain, Fab 136 anti-SIRP-alpha antibody Variable Light Chain, Tyrosine-protein phosphatase non-receptor type substrate 1 | Authors: | Wibowo, A.S, Carter, J.J, Sim, J. | Deposit date: | 2019-01-11 | Release date: | 2019-08-07 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRP alpha. Mabs, 11, 2019
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6NMU
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![BU of 6nmu by Molmil](/molmil-images/mine/6nmu) | Kick-Off Fab 115 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1 | Descriptor: | Fab 115 anti-SIRP-alpha antibody Variable Heavy Chain, Fab 115 anti-SIRP-alpha antibody Variable Light Chain, Tyrosine-protein phosphatase non-receptor type substrate 1 | Authors: | Wibowo, A.S, Carter, J.J, Sim, J. | Deposit date: | 2019-01-11 | Release date: | 2019-08-07 | Last modified: | 2019-08-14 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRP alpha. Mabs, 11, 2019
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1GBG
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![BU of 1gbg by Molmil](/molmil-images/mine/1gbg) | BACILLUS LICHENIFORMIS BETA-GLUCANASE | Descriptor: | (1,3-1,4)-BETA-D-GLUCAN 4 GLUCANOHYDROLASE, CALCIUM ION | Authors: | Hahn, M, Heinemann, U. | Deposit date: | 1995-08-25 | Release date: | 1995-12-07 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of Bacillus licheniformis 1,3-1,4-beta-D-glucan 4-glucanohydrolase at 1.8 A resolution. FEBS Lett., 374, 1995
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5D1X
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![BU of 5d1x by Molmil](/molmil-images/mine/5d1x) | IsdB NEAT2 bound by D4-30 | Descriptor: | D4-30 Heavy Chain, D4-30 Light Chain, Iron-regulated surface determinant protein B, ... | Authors: | Deng, X. | Deposit date: | 2015-08-04 | Release date: | 2016-08-10 | Last modified: | 2016-12-07 | Method: | X-RAY DIFFRACTION (3.21 Å) | Cite: | Germline-encoded neutralization of a Staphylococcus aureus virulence factor by the human antibody repertoire. Nat Commun, 7, 2016
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3U0T
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![BU of 3u0t by Molmil](/molmil-images/mine/3u0t) | Fab-antibody complex | Descriptor: | Amyloid beta A4 protein, ponezumab HC Fab, ponezumab LC Fab | Authors: | LaPorte, S.L, Pons, J.P. | Deposit date: | 2011-09-29 | Release date: | 2012-01-11 | Last modified: | 2013-07-03 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Basis of C-terminal beta-Amyloid Peptide Binding by the Antibody Ponezumab for the Treatment of Alzheimer's Disease J.Mol.Biol., 421, 2012
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4DZ8
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![BU of 4dz8 by Molmil](/molmil-images/mine/4dz8) | human IgG1 Fc fragment Heterodimer | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Ig gamma-1 chain C region | Authors: | Strop, P. | Deposit date: | 2012-02-29 | Release date: | 2012-08-01 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Generating Bispecific Human IgG1 and IgG2 Antibodies from Any Antibody Pair. J.Mol.Biol., 420, 2012
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3SQO
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![BU of 3sqo by Molmil](/molmil-images/mine/3sqo) | PCSK9 J16 Fab complex | Descriptor: | J16 Heavy chain, J16 Light chain, PCSK9 prodomain, ... | Authors: | Strop, P. | Deposit date: | 2011-07-05 | Release date: | 2012-05-16 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Proprotein convertase substilisin/kexin type 9 antagonism reduces low-density lipoprotein cholesterol in statin-treated hypercholesterolemic nonhuman primates. J.Pharmacol.Exp.Ther., 340, 2012
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4EDX
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![BU of 4edx by Molmil](/molmil-images/mine/4edx) | Nerve Growth Factor in Complex with Fab from mouse mAb 911 | Descriptor: | Beta-nerve growth factor, heavy chain of Fab of murine anti-NGF, light chain of FAB of murine anti-NGF | Authors: | Eigenbrot, C, Ultsch, M. | Deposit date: | 2012-03-27 | Release date: | 2014-04-02 | Last modified: | 2014-08-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexes. MAbs, 6
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4EDW
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![BU of 4edw by Molmil](/molmil-images/mine/4edw) | |
5EPM
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![BU of 5epm by Molmil](/molmil-images/mine/5epm) | |
3D6E
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![BU of 3d6e by Molmil](/molmil-images/mine/3d6e) | Crystal structure of the engineered 1,3-1,4-beta-glucanase protein from Bacillus licheniformis | Descriptor: | Beta-glucanase, CALCIUM ION | Authors: | Fita, I, Planas, A, Calisto, B.M, Addington, T. | Deposit date: | 2008-05-19 | Release date: | 2009-05-19 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Re-engineering specificity in 1,3-1,4-beta-glucanase to accept branched xyloglucan substrates Proteins, 79, 2011
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