6NMU

Kick-Off Fab 115 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1

Summary for 6NMU

• Entry DOI: 10.2210/pdb6nmu/pdb
• Related: 6NMR 6NMS 6NMT
• Descriptor: Fab 115 anti-SIRP-alpha antibody Variable Light Chain, Fab 115 anti-SIRP-alpha antibody Variable Heavy Chain, Tyrosine-protein phosphatase non-receptor type substrate 1, ... (4 entities in total)
• Functional Keywords: sirp-alpha, signal regulatory protein alpha, signal-regulatory protein alpha, tyrosine-protein phosphatase non-receptor type substrate 1, cd47, cluster of differentiation 47, anti-sirp-alpha antibody, blocking anti-sirp-alpha antibody, non-blocking anti-sirp-alpha antibody, kick-off anti-sirp-alpha antibody, anti-sirp-alpha antibody in complex with sirp-alpha, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 124061.93

Authors

Wibowo, A.S.,Carter, J.J.,Sim, J. (deposition date: 2019-01-11, release date: 2019-08-07, Last modification date: 2019-08-14)

• Primary citation: Sim, J.,Sockolosky, J.T.,Sangalang, E.,Izquierdo, S.,Pedersen, D.,Harriman, W.,Wibowo, A.S.,Carter, J.,Madan, A.,Doyle, L.,Harrabi, O.,Kauder, S.E.,Chen, A.,Kuo, T.C.,Wan, H.,Pons, J.; Discovery of high affinity, pan-allelic, and pan-mammalian reactive antibodies against the myeloid checkpoint receptor SIRP alpha.; Mabs, 11:1036-1052, 2019; PubMed: 31257988; DOI: 10.1080/19420862.2019.1624123

Experimental method

X-RAY DIFFRACTION (2.55 Å)