6NMU

Kick-Off Fab 115 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (L, A)	Fab 115 anti-SIRP-alpha antibody Variable Light Chain	polymer	215	23575.1	2		Homo sapiens (human)
2	B, E (H, B)	Fab 115 anti-SIRP-alpha antibody Variable Heavy Chain	polymer	228	24424.1	2		Homo sapiens (human)
3	C, F (S, C)	Tyrosine-protein phosphatase non-receptor type substrate 1	polymer	127	14031.8	2	UniProt (P78324) Pfam (PF07686)	Homo sapiens (Human)	SHPS-1,Brain Ig-like molecule with tyrosine-based activation motifs,Bit,CD172 antigen-like family member A,Inhibitory receptor SHPS-1,Macrophage fusion receptor,MyD-1 antigen,Signal-regulatory protein alpha-1,Sirp-alpha-1,Signal-regulatory protein alpha-2,Sirp-alpha-2,Signal-regulatory protein alpha-3,Sirp-alpha-3,p84
4	G, H, I, J, K... (L, H, S, A, B...)	water	water		18.0	271	Chemie (HOH)

Sequence modifications

S, C: 1 - 119 (UniProt: P78324)

PDB	External Database	Details
Ala 80	Asn 110	conflict
Thr 120	-	expression tag
Arg 121	-	expression tag
His 122	-	expression tag
His 123	-	expression tag
His 124	-	expression tag
His 125	-	expression tag
His 126	-	expression tag
His 127	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	124061.9
All*	Total formula weight	124061.9

*Water molecules are not included.