4EDX

Nerve Growth Factor in Complex with Fab from mouse mAb 911

Summary for 4EDX

• Entry DOI: 10.2210/pdb4edx/pdb
• Related: 4EDW
• Descriptor: Beta-nerve growth factor, light chain of FAB of murine anti-NGF, heavy chain of Fab of murine anti-NGF, ... (4 entities in total)
• Functional Keywords: cystine knot, immunoglobulin, growth/survival factor, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted: P01138
• Total number of polymer chains: 6
• Total formula weight: 121951.98

Authors

Eigenbrot, C.,Ultsch, M. (deposition date: 2012-03-27, release date: 2014-04-02, Last modification date: 2014-08-13)

• Primary citation: La Porte, S.L.,Eigenbrot, C.,Ultsch, M.,Ho, W.H.,Foletti, D.,Forgie, A.,Lindquist, K.C.,Shelton, D.L.,Pons, J.; Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexes.; MAbs, 6:1059-1068, ; PubMed: 24830649

Experimental method

X-RAY DIFFRACTION (2.5 Å)