4EDW
Nerve Growth Factor in Complex with Fab from humanized version of mouse mAb 911 (tanezumab)
Summary for 4EDW
Entry DOI | 10.2210/pdb4edw/pdb |
Related | 4EDX |
Descriptor | Beta-nerve growth factor, tanezumab Fab light chain, tanezumab Fab heavy chain, ... (5 entities in total) |
Functional Keywords | cystine knot, immunoglobulin, growth/survival factor, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P01138 |
Total number of polymer chains | 3 |
Total formula weight | 62188.41 |
Authors | Eigenbrot, C.,Ultsch, M. (deposition date: 2012-03-27, release date: 2014-04-02, Last modification date: 2017-10-25) |
Primary citation | La Porte, S.L.,Eigenbrot, C.,Ultsch, M.,Ho, W.H.,Foletti, D.,Forgie, A.,Lindquist, K.C.,Shelton, D.L.,Pons, J. Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexes. MAbs, 6:1059-1068, Cited by PubMed: 24830649PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.48 Å) |
Structure validation
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