4EDX
Nerve Growth Factor in Complex with Fab from mouse mAb 911
Summary for 4EDX
Entry DOI | 10.2210/pdb4edx/pdb |
Related | 4EDW |
Descriptor | Beta-nerve growth factor, light chain of FAB of murine anti-NGF, heavy chain of Fab of murine anti-NGF, ... (4 entities in total) |
Functional Keywords | cystine knot, immunoglobulin, growth/survival factor, immune system |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P01138 |
Total number of polymer chains | 6 |
Total formula weight | 121951.98 |
Authors | Eigenbrot, C.,Ultsch, M. (deposition date: 2012-03-27, release date: 2014-04-02, Last modification date: 2014-08-13) |
Primary citation | La Porte, S.L.,Eigenbrot, C.,Ultsch, M.,Ho, W.H.,Foletti, D.,Forgie, A.,Lindquist, K.C.,Shelton, D.L.,Pons, J. Generation of a high-fidelity antibody against nerve growth factor using library scanning mutagenesis and validation with structures of the initial and optimized Fab-antigen complexes. MAbs, 6:1059-1068, Cited by PubMed: 24830649PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
Download full validation report