7KPG
Blocking Fab 25 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1
Summary for 7KPG
Entry DOI | 10.2210/pdb7kpg/pdb |
Descriptor | Heavy chain of Fab 25 anti-SIRP-alpha antibody, Light chain of Fab 25 anti-SIRP-alpha antibody, Tyrosine-protein phosphatase non-receptor type substrate 1, ... (5 entities in total) |
Functional Keywords | sirpa antibody complex, signal regulatory protein alpha variant 1, signaling protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 58197.51 |
Authors | |
Primary citation | Kuo, T.C.,Chen, A.,Harrabi, O.,Sockolosky, J.T.,Zhang, A.,Sangalang, E.,Doyle, L.V.,Kauder, S.E.,Fontaine, D.,Bollini, S.,Han, B.,Fu, Y.X.,Sim, J.,Pons, J.,Wan, H.I. Targeting the myeloid checkpoint receptor SIRP alpha potentiates innate and adaptive immune responses to promote anti-tumor activity. J Hematol Oncol, 13:160-160, 2020 Cited by PubMed: 33256806DOI: 10.1186/s13045-020-00989-w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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