7KPG

Blocking Fab 25 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1

Summary for 7KPG

• Entry DOI: 10.2210/pdb7kpg/pdb
• Descriptor: Heavy chain of Fab 25 anti-SIRP-alpha antibody, Light chain of Fab 25 anti-SIRP-alpha antibody, Tyrosine-protein phosphatase non-receptor type substrate 1, ... (5 entities in total)
• Functional Keywords: sirpa antibody complex, signal regulatory protein alpha variant 1, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 58197.51

Authors

Sim, J.,Pons, J. (deposition date: 2020-11-11, release date: 2020-12-16, Last modification date: 2023-10-18)

• Primary citation: Kuo, T.C.,Chen, A.,Harrabi, O.,Sockolosky, J.T.,Zhang, A.,Sangalang, E.,Doyle, L.V.,Kauder, S.E.,Fontaine, D.,Bollini, S.,Han, B.,Fu, Y.X.,Sim, J.,Pons, J.,Wan, H.I.; Targeting the myeloid checkpoint receptor SIRP alpha potentiates innate and adaptive immune responses to promote anti-tumor activity.; J Hematol Oncol, 13:160-160, 2020; PubMed: 33256806; DOI: 10.1186/s13045-020-00989-w

Experimental method

X-RAY DIFFRACTION (2.27 Å)