7KPG
Blocking Fab 25 anti-SIRP-alpha antibody in complex with SIRP-alpha Variant 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (H) | Heavy chain of Fab 25 anti-SIRP-alpha antibody | polymer | 212 | 22566.2 | 1 | Homo sapiens | ||
| 2 | B (L) | Light chain of Fab 25 anti-SIRP-alpha antibody | polymer | 212 | 22648.8 | 1 | Homo sapiens | ||
| 3 | C (S) | Tyrosine-protein phosphatase non-receptor type substrate 1 | polymer | 115 | 12502.2 | 1 | UniProt (P78324) Pfam (PF07686) | Homo sapiens (Human) | SHPS-1,Brain Ig-like molecule with tyrosine-based activation motifs,Bit,CD172 antigen-like family member A,Inhibitory receptor SHPS-1,Macrophage fusion receptor,MyD-1 antigen,Signal-regulatory protein alpha-1,Sirp-alpha-1,Signal-regulatory protein alpha-2,Sirp-alpha-2,Signal-regulatory protein alpha-3,Sirp-alpha-3,p84 |
| 4 | D, E, F, G, H (H, L, S) | SULFATE ION | non-polymer | 96.1 | 5 | Chemie (SO4) | |||
| 5 | I, J, K (H, L, S) | water | water | 18.0 | 166 | Chemie (HOH) |
Sequence modifications
S: 3 - 117 (UniProt: P78324)
| PDB | External Database | Details |
|---|---|---|
| Ala 80 | Asn 110 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 57717.2 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 480.3 | |
| All* | Total formula weight | 58197.5 |
