3SJ9
| crystal structure of the C147A mutant 3C of CVA16 in complex with FAGLRQAVTQ peptide | Descriptor: | 3C protease, FAGLRQAVTQ peptide | Authors: | Lu, G, Qi, J, Chen, Z, Xu, X, Gao, F, Lin, D, Qian, W, Liu, H, Jiang, H, Yan, J, Gao, G.F. | Deposit date: | 2011-06-21 | Release date: | 2011-08-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.399 Å) | Cite: | Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design. J.Virol., 85, 2011
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3SJK
| Crystal structure of the C147A mutant 3C from enterovirus 71 | Descriptor: | 3C protease, KPVLRTATVQGPSLDF peptide | Authors: | Lu, G, Qi, J, Chen, Z, Xu, X, Gao, F, Lin, D, Qian, W, Liu, H, Jiang, H, Yan, J, Gao, G.F. | Deposit date: | 2011-06-21 | Release date: | 2011-08-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.096 Å) | Cite: | Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design. J.Virol., 85, 2011
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5ZZ9
| Crystal structure of Homer2 EVH1/Drebrin PPXXF complex | Descriptor: | Homer protein homolog 2, Peptide from Drebrin | Authors: | Li, Z, Liu, H, Li, J, Liu, W, Zhang, M. | Deposit date: | 2018-05-31 | Release date: | 2018-12-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Homer Tetramer Promotes Actin Bundling Activity of Drebrin. Structure, 27, 2019
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3B3Q
| Crystal structure of a synaptic adhesion complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Chen, X, Liu, H, Shim, A, Focia, P, He, X. | Deposit date: | 2007-10-22 | Release date: | 2008-01-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis for synaptic adhesion mediated by neuroligin-neurexin interactions. Nat.Struct.Mol.Biol., 15, 2008
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3EJJ
| Structure of M-CSF bound to the first three domains of FMS | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Colony stimulating factor-1, Macrophage colony-stimulating factor 1 receptor | Authors: | Chen, X, Liu, H, Focia, P.J, Shim, A, He, X. | Deposit date: | 2008-09-18 | Release date: | 2008-12-09 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases. Proc.Natl.Acad.Sci.USA, 105, 2008
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3QTF
| Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity | Descriptor: | (6S)-6,15,15,18-tetramethyl-17-oxo-2,3,4,5,6,7,14,15,16,17-decahydro-1H-8,12-(metheno)[1,4,9]triazacyclotetradecino[9,8-a]indole-9-carboxamide, DIMETHYL SULFOXIDE, Heat shock protein HSP 90-alpha | Authors: | Zapf, C.W, Bloom, J.D, McBean, J.L, Dushin, R.G, Nittoli, T, Ingalls, C, Sutherland, A.G, Sonye, J.P, Eid, C.N, Golas, J, Liu, H, Boschelli, F, Hu, Y, Vogan, E.M, Levin, J.I. | Deposit date: | 2011-02-22 | Release date: | 2011-04-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.5703 Å) | Cite: | Design and SAR of macrocyclic Hsp90 inhibitors with increased metabolic stability and potent cell-proliferation activity. Bioorg.Med.Chem.Lett., 21, 2011
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3FFE
| Structure of Achromobactin Synthetase Protein D, (AcsD) | Descriptor: | AcsD | Authors: | McMahon, S.A, Liu, H, Carter, L, Oke, M, Johnson, K.A, Schmelz, S, Challis, G.L, White, M.F, Naismith, J.H, Scottish Structural Proteomics Facility (SSPF) | Deposit date: | 2008-12-03 | Release date: | 2009-02-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | AcsD catalyzes enantioselective citrate desymmetrization in siderophore biosynthesis Nat.Chem.Biol., 5, 2009
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3RKZ
| Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor capable of significantly decreasing tumor volume in a mouse xenograft model. | Descriptor: | (5R,6S)-3-(L-alanyl)-5,6,15,15,18-pentamethyl-17-oxo-2,3,4,5,6,7,14,15,16,17-decahydro-1H-12,8-(metheno)[1,5,9]triazacyclotetradecino[1,2-a]indole-9-carboxamide, Heat shock protein HSP 90-alpha | Authors: | Zapf, C.W, Bloom, J.D, Li, Z, Dushin, R.G, Nittoli, T, Otteng, M, Nikitenko, A, Golas, J.M, Liu, H, Lucas, J, Boschelli, F, Vogan, E, Olland, A, Johnson, M, Levin, J.I. | Deposit date: | 2011-04-18 | Release date: | 2011-07-13 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.5693 Å) | Cite: | Discovery of a stable macrocyclic o-aminobenzamide Hsp90 inhibitor which significantly decreases tumor volume in a mouse xenograft model. Bioorg.Med.Chem.Lett., 21, 2011
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2MLB
| NMR solution structure of a computational designed protein based on template of human erythrocytic ubiquitin | Descriptor: | redesigned ubiquitin | Authors: | Xiong, P, Wang, M, Zhang, J, Chen, Q, Liu, H. | Deposit date: | 2014-02-21 | Release date: | 2014-10-29 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Protein design with a comprehensive statistical energy function and boosted by experimental selection for foldability Nat Commun, 5, 2014
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2MN4
| NMR solution structure of a computational designed protein based on structure template 1cy5 | Descriptor: | Computational designed protein based on structure template 1cy5 | Authors: | Xiong, P, Wang, M, Zhang, J, Chen, Q, Liu, H. | Deposit date: | 2014-03-28 | Release date: | 2014-10-29 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Protein design with a comprehensive statistical energy function and boosted by experimental selection for foldability Nat Commun, 5, 2014
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5YFG
| SOLUTION STRUCTURE OF HUMAN MOG1 | Descriptor: | Ran guanine nucleotide release factor | Authors: | Hu, Q, Liu, Y, Bao, X, Liu, H. | Deposit date: | 2017-09-21 | Release date: | 2017-11-01 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Mitosis-specific acetylation tunes Ran effector binding for chromosome segregation J Mol Cell Biol, 10, 2018
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7UEB
| Photosynthetic assembly of Chlorobaculum tepidum (RC-FMO2) | Descriptor: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, 2-[(1E,3E,5E,7E,9E,11E,13E,15E,17E,19E)-3,7,12,16,20,24-hexamethylpentacosa-1,3,5,7,9,11,13,15,17,19,23-undecaenyl]-1,3,4-trimethyl-benzene, ... | Authors: | Puskar, R, Truong, C.D, Swain, K, Li, S, Cheng, K.-W, Wang, T.Y, Poh, Y.-P, Liu, H, Chou, T.-F, Nannenga, B, Chiu, P.-L. | Deposit date: | 2022-03-21 | Release date: | 2022-10-05 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (3.08 Å) | Cite: | Molecular asymmetry of a photosynthetic supercomplex from green sulfur bacteria. Nat Commun, 13, 2022
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7UEA
| Photosynthetic assembly of Chlorobaculum tepidum (RC-FMO1) | Descriptor: | 1,2-DIPALMITOYL-PHOSPHATIDYL-GLYCEROLE, 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, 2-[(1E,3E,5E,7E,9E,11E,13E,15E,17E,19E)-3,7,12,16,20,24-hexamethylpentacosa-1,3,5,7,9,11,13,15,17,19,23-undecaenyl]-1,3,4-trimethyl-benzene, ... | Authors: | Puskar, R, Truong, C.D, Swain, K, Li, S, Cheng, K.-W, Wang, T.Y, Poh, Y.-P, Liu, H, Chou, T.-F, Nannenga, B, Chiu, P.-L. | Deposit date: | 2022-03-21 | Release date: | 2022-10-05 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (3.49 Å) | Cite: | Molecular asymmetry of a photosynthetic supercomplex from green sulfur bacteria. Nat Commun, 13, 2022
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4GXB
| Structure of the SNX17 atypical FERM domain bound to the NPxY motif of P-selectin | Descriptor: | GLYCEROL, P-selectin, Sorting nexin-17 | Authors: | Ghai, R, Bugarcic, A, Liu, H, Norwood, S.J, Li, S.S, Teasdale, R.D, Collins, B.M. | Deposit date: | 2012-09-04 | Release date: | 2013-03-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc.Natl.Acad.Sci.USA, 110, 2013
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7DGY
| De novo designed protein H4C2R | Descriptor: | de novo designed protein H4C2R | Authors: | Xu, Y, Liao, S, Chen, Q, Liu, H. | Deposit date: | 2020-11-12 | Release date: | 2021-12-15 | Last modified: | 2022-03-02 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A backbone-centred energy function of neural networks for protein design. Nature, 602, 2022
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2IX2
| Crystal structure of the heterotrimeric PCNA from Sulfolobus solfataricus | Descriptor: | DNA POLYMERASE SLIDING CLAMP A, DNA POLYMERASE SLIDING CLAMP B, DNA POLYMERASE SLIDING CLAMP C | Authors: | Williams, G.J, Johnson, K, McMahon, S.A, Carter, L, Oke, M, Liu, H, Taylor, G.L, White, M.F, Naismith, J.H. | Deposit date: | 2006-07-05 | Release date: | 2006-10-04 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the Heterotrimeric PCNA from Sulfolobus Solfataricus. Acta Crystallogr.,Sect.F, 62, 2006
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4J2T
| Inhibitor-bound Ca2+ ATPase | Descriptor: | (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-3a,4-bis(butanoyloxy)-3-hydroxy-3,6,9-trimethyl-8-{[(2E)-2-methylbut-2-enoyl]oxy}-2-oxo-2,3,3a,4,5,6,6a,7,8,9b-decahydroazuleno[4,5-b]furan-7-yl octanoate, PHOSPHATIDYLETHANOLAMINE, POTASSIUM ION, ... | Authors: | Paulsen, E.S, Villadsen, J, Tenori, E, Liu, H, Lie, M.A, Bonde, D.F, Bublitz, M, Olesen, C, Autzen, H.E, Dach, I, Sehgal, P, Moller, J.V, Schiott, B, Nissen, P, Christensen, S.B. | Deposit date: | 2013-02-05 | Release date: | 2013-06-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Water-mediated interactions influence the binding of thapsigargin to sarco/endoplasmic reticulum calcium adenosinetriphosphatase. J.Med.Chem., 56, 2013
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2JG2
| HIGH RESOLUTION STRUCTURE OF SPT WITH PLP INTERNAL ALDIMINE | Descriptor: | MAGNESIUM ION, PYRIDOXAL-5'-PHOSPHATE, SERINE PALMITOYLTRANSFERASE | Authors: | Yard, B.A, Carter, L.G, Johnson, K.A, Overton, I.M, Mcmahon, S.A, Dorward, M, Liu, H, Puech, D, Oke, M, Barton, G.J, Naismith, J.H, Campopiano, D.J. | Deposit date: | 2007-02-07 | Release date: | 2007-05-01 | Last modified: | 2015-11-11 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | The Structure of Serine Palmitoyltransferase; Gateway to Sphingolipid Biosynthesis. J.Mol.Biol., 370, 2007
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2JGT
| Low resolution structure of SPT | Descriptor: | SERINE PALMITOYLTRANSFERASE | Authors: | Yard, B.A, Carter, L.G, Johnson, K.A, Overton, I.M, Mcmahon, S.A, Dorward, M, Liu, H, Puech, D, Oke, M, Barton, G.J, Naismith, J.H, Campopiano, D.J. | Deposit date: | 2007-02-14 | Release date: | 2007-05-01 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | The Structure of Serine Palmitoyltransferase; Gateway to Sphingolipid Biosynthesis. J.Mol.Biol., 370, 2007
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4MQW
| Structure of follicle-stimulating hormone in complex with the entire ectodomain of its receptor (P31) | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Follicle-stimulating hormone receptor, ... | Authors: | Jiang, X, Liu, H, Chen, X, He, X. | Deposit date: | 2013-09-16 | Release date: | 2014-04-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Evidence for Follicle-stimulating Hormone Receptor as a Functional Trimer. J.Biol.Chem., 289, 2014
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8HND
| Cryo-EM structure of human OATP1B1 in complex with estrone-3-sulfate | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier organic anion transporter family member 1B1, ... | Authors: | Shan, Z, Yang, X, Liu, H, Nan, J, Yuan, Y, Zhang, Y. | Deposit date: | 2022-12-07 | Release date: | 2023-09-13 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Cryo-EM structures of human organic anion transporting polypeptide OATP1B1. Cell Res., 33, 2023
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8HNC
| Cryo-EM structure of human OATP1B1 in complex with bilirubin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(Z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, ... | Authors: | Shan, Z, Yang, X, Liu, H, Nan, J, Yuan, Y, Zhang, Y. | Deposit date: | 2022-12-07 | Release date: | 2023-09-13 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.73 Å) | Cite: | Cryo-EM structures of human organic anion transporting polypeptide OATP1B1. Cell Res., 33, 2023
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8JPD
| Focused refinement structure of GRK2 in NTSR1-GRK2-Galpha(q) complexes | Descriptor: | Beta-adrenergic receptor kinase 1, STAUROSPORINE | Authors: | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | Deposit date: | 2023-06-11 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.81 Å) | Cite: | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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8JPC
| cryo-EM structure of NTSR1-GRK2-Galpha(q) complexes 2 | Descriptor: | 2-[{2-(1-fluorocyclopropyl)-4-[4-(2-methoxyphenyl)piperidin-1-yl]quinazolin-6-yl}(methyl)amino]ethan-1-ol, Beta-adrenergic receptor kinase 1, GUANOSINE-5'-DIPHOSPHATE, ... | Authors: | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | Deposit date: | 2023-06-11 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (3.07 Å) | Cite: | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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8JPE
| Focused refinement structure of Galpha(q) in NTSR1-GRK2-Galpha(q) complexes | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, Guanine nucleotide-binding protein G(q) subunit alpha, MAGNESIUM ION, ... | Authors: | Duan, J, Liu, H, Zhao, F, Yuan, Q, Ji, Y, Xu, H.E. | Deposit date: | 2023-06-11 | Release date: | 2023-08-09 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.91 Å) | Cite: | GPCR activation and GRK2 assembly by a biased intracellular agonist. Nature, 620, 2023
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