3EJJ

Structure of M-CSF bound to the first three domains of FMS

Summary for 3EJJ

Entry DOI	10.2210/pdb3ejj/pdb
Descriptor	Colony stimulating factor-1, Macrophage colony-stimulating factor 1 receptor, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	growth factor-receptor complex, receptor tyrosine kinase, cytokine, 4-helix bundle, atp-binding, glycoprotein, immunoglobulin domain, kinase, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, receptor, transferase, transmembrane, tyrosine-protein kinase, cytokine-signaling protein complex, cytokine/signaling protein
Biological source	Mus musculus (mouse) More
Total number of polymer chains	3
Total formula weight	69289.66
Authors	Chen, X.,Liu, H.,Focia, P.J.,Shim, A.,He, X. (deposition date: 2008-09-18, release date: 2008-12-09, Last modification date: 2023-08-30)
Primary citation	Chen, X.,Liu, H.,Focia, P.J.,Shim, A.H.,He, X. Structure of macrophage colony stimulating factor bound to FMS: diverse signaling assemblies of class III receptor tyrosine kinases. Proc.Natl.Acad.Sci.USA, 105:18267-18272, 2008 Cited by PubMed: 19017797 DOI: 10.1073/pnas.0807762105 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation