3EJJ

Structure of M-CSF bound to the first three domains of FMS

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Colony stimulating factor-1	polymer	155	18194.3	2	UniProt (Q3U395) Pfam (PF05337) UniProt (by SIFTS) (P07141)	Mus musculus (mouse)
2	C (X)	Macrophage colony-stimulating factor 1 receptor	polymer	289	32052.2	1	UniProt (P09581) Pfam (PF00047)	Mus musculus (mouse)	CSF-1-R, Fms proto-oncogene, c-fms
3	D, E (C, D)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	2	In PDB GlyTouCan (G42666HT)
4	F, G, H (A, B, X)	water	water		18.0	654	Chemie (HOH)

Sequence modifications

A, B: 4 - 148 (UniProt: Q3U395)

PDB	External Database	Details
Ala 1	-	expression tag
Asp 2	-	expression tag
Pro 3	-	expression tag
His 149	-	expression tag
His 150	-	expression tag
His 151	-	expression tag
His 152	-	expression tag
His 153	-	expression tag
His 154	-	expression tag
His 155	-	expression tag

X: 20 - 296 (UniProt: P09581)

PDB	External Database	Details
Ala 17	-	expression tag
Asp 18	-	expression tag
Pro 19	-	expression tag
Glu 297	-	expression tag
Ser 298	-	expression tag
His 299	-	expression tag
His 300	-	expression tag
His 301	-	expression tag
His 302	-	expression tag
His 303	-	expression tag
His 304	-	expression tag
His 305	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	68440.9
Branched	Number of molecules	2
	Total formula weight	848.8
All*	Total formula weight	69289.7

*Water molecules are not included.