6HN4
 
 | | Leucine-zippered human insulin receptor ectodomain with single bound insulin - "lower" membrane-proximal part | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin receptor,Insulin receptor,General control protein GCN4 | | 著者 | Weis, F, Menting, J.G, Margetts, M.B, Chan, S.J, Xu, Y, Tennagels, N, Wohlfart, P, Langer, T, Mueller, C.W, Dreyer, M.K, Lawrence, M.C. | | 登録日 | 2018-09-14 | | 公開日 | 2018-11-21 | | 最終更新日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | The signalling conformation of the insulin receptor ectodomain.
Nat Commun, 9, 2018
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1F5Z
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1F6P
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1F6K
 | | CRYSTAL STRUCTURE ANALYSIS OF N-ACETYLNEURAMINATE LYASE FROM HAEMOPHILUS INFLUENZAE: CRYSTAL FORM II | | 分子名称: | GLYCEROL, N-ACETYLNEURAMINATE LYASE, SULFATE ION | | 著者 | Barbosa, J.A.R.G, Smith, B.J, DeGori, R, Lawrence, M.C. | | 登録日 | 2000-06-21 | | 公開日 | 2000-12-20 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme.
J.Mol.Biol., 303, 2000
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1F74
 | | CRYSTAL STRUCTURE ANALYSIS OF N-ACETYLNEURAMINATE LYASE FROM HAEMOPHILUS INFLUENZAE: CRYSTAL FORM II COMPLEXED WITH 4-DEOXY-SIALIC ACID | | 分子名称: | 6,7,8,9-TETRAHYDROXY-5-METHYLCARBOXAMIDO-2-OXONONANOIC ACID, CHLORIDE ION, GLYCEROL, ... | | 著者 | Barbosa, J.A.R.G, Smith, B.J, DeGori, R, Lawrence, M.C. | | 登録日 | 2000-06-26 | | 公開日 | 2000-11-22 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme.
J.Mol.Biol., 303, 2000
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1F7B
 | | CRYSTAL STRUCTURE ANALYSIS OF N-ACETYLNEURAMINATE LYASE FROM HAEMOPHILUS INFLUENZAE: CRYSTAL FORM II IN COMPLEX WITH 4-OXO-SIALIC ACID | | 分子名称: | 4,4,6,7,8,9-HEXAHYDROXY-5-METHYLCARBOXAMIDONONANOIC ACID, 6,7,8,9-TETRAHYDROXY-5-METHYLCARBOXAMIDO-4-OXONONANOIC ACID, CHLORIDE ION, ... | | 著者 | Barbosa, J.A.R.G, Smith, B.J, DeGori, R, Lawrence, M.C. | | 登録日 | 2000-06-26 | | 公開日 | 2000-11-22 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme.
J.Mol.Biol., 303, 2000
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1F73
 | | CRYSTAL STRUCTURE ANALYSIS OF N-ACETYLNEURAMINATE LYASE FROM HAEMOPHILUS INFLUENZAE: CRYSTAL FORM III IN COMPLEX WITH SIALIC ACID ALDITOL | | 分子名称: | 2,4,6,7,8,9-HEXAHYDROXY-5-METHYLCARBOXAMIDO NONANOIC ACID, GLYCEROL, N-ACETYL NEURAMINATE LYASE | | 著者 | Barbosa, J.A.R.G, Smith, B.J, DeGori, R, Lawrence, M.C. | | 登録日 | 2000-06-25 | | 公開日 | 2000-11-22 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme.
J.Mol.Biol., 303, 2000
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1NAL
 | | THE THREE-DIMENSIONAL STRUCTURE OF N-ACETYLNEURAMINATE LYASE FROM ESCHERICHIA COLI | | 分子名称: | N-ACETYLNEURAMINATE LYASE, SULFATE ION | | 著者 | Izard, T, Lawrence, M.C, Malby, R.L, Lilley, G.G, Colman, P.M. | | 登録日 | 1994-02-28 | | 公開日 | 1995-09-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli.
Structure, 2, 1994
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1Z5X
 | | hemipteran ecdysone receptor ligand-binding domain complexed with ponasterone A | | 分子名称: | 2,3,14,20,22-PENTAHYDROXYCHOLEST-7-EN-6-ONE, Ecdysone receptor ligand binding domain, PHOSPHATE ION, ... | | 著者 | Carmichael, J.A, Lawrence, M.C, Graham, L.D, Pilling, P.A, Epa, V.C, Noyce, L, Lovrecz, G, Winkler, D.A, Pawlak-Skrzecz, A. | | 登録日 | 2005-03-21 | | 公開日 | 2005-04-05 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (3.07 Å) | | 主引用文献 | The X-ray structure of a hemipteran ecdysone receptor ligand-binding domain: comparison with a lepidopteran ecdysone receptor ligand-binding domain and implications for insecticide design.
J.Biol.Chem., 280, 2005
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4ZXB
 | | Structure of the human insulin receptor ectodomain, IRDeltabeta construct, in complex with four Fab molecules | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Croll, T, Smith, B.J, Margetts, M.B, Whittaker, J, Weiss, M.A, Ward, C.W, Lawrence, M.C. | | 登録日 | 2015-05-20 | | 公開日 | 2016-02-24 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Higher-Resolution Structure of the Human Insulin Receptor Ectodomain: Multi-Modal Inclusion of the Insert Domain.
Structure, 24, 2016
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7U6E
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7U6D
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4NIB
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6VER
 | | Human insulin analog: [GluB10,TyrB20]-DOI | | 分子名称: | Insulin A chain, Insulin B chain | | 著者 | Menting, J.G, Chou, D.H.-C, Lawrence, M.C, Xiong, X. | | 登録日 | 2020-01-02 | | 公開日 | 2020-11-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.047 Å) | | 主引用文献 | Mini-Ins: A minimal, bioactive insulin analog with alternative binding modes
not published
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6VET
 | | Human insulin analog: [GluB10,HisA8,ArgA9,TyrB20]-DOI | | 分子名称: | Insulin A chain, Insulin B chain | | 著者 | Menting, J.G, Chou, D.H.-C, Lawrence, M.C, Xiong, X. | | 登録日 | 2020-01-02 | | 公開日 | 2020-06-03 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.46 Å) | | 主引用文献 | A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
Nat.Struct.Mol.Biol., 27, 2020
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6VEQ
 | | Con-Ins G1 in complex with the human insulin microreceptor in turn in complex with Fv 83-7 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Con-Ins G1 B chain, Con-Ins G1a A chain, ... | | 著者 | Menting, J.G, Chou, D.H.-C, Lawrence, M.C, Xiong, X. | | 登録日 | 2020-01-02 | | 公開日 | 2020-06-03 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | | 主引用文献 | A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
Nat.Struct.Mol.Biol., 27, 2020
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6VES
 | | Human insulin analog: [GluB10,HisA8,ArgA9]-DOI | | 分子名称: | Insulin A chain, Insulin B chain | | 著者 | Menting, J.G, Chou, D.H.-C, Lawrence, M.C, Xiong, X. | | 登録日 | 2020-01-02 | | 公開日 | 2020-11-11 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Mini-Ins: A Minimal, Bioactive Insulin Analog with Alternative Binding Modes
To Be Published
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6VWI
 | | Head region of the closed conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor II, Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain | | 著者 | Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I. | | 登録日 | 2020-02-19 | | 公開日 | 2020-05-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Structure, 28, 2020
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6VWH
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6VWG
 | | Head region of the open conformation of the human type 1 insulin-like growth factor receptor ectodomain in complex with human insulin-like growth factor II. | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin-like growth factor II, Leucine-zippered human type 1 insulin-like growth factor receptor ectodomain | | 著者 | Xu, Y, Kirk, N.S, Lawrence, M.C, Croll, T.I. | | 登録日 | 2020-02-19 | | 公開日 | 2020-05-13 | | 最終更新日 | 2020-07-29 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | How IGF-II Binds to the Human Type 1 Insulin-like Growth Factor Receptor.
Structure, 28, 2020
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6VWJ
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7S8V
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7S0Q
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7U23
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7MQO
 | | The insulin receptor ectodomain in complex with a venom hybrid insulin analog - "head" region | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Insulin A chain, ... | | 著者 | Blakely, A.D, Xiong, X, Kim, J.H, Menting, J, Schafer, I.B, Schubert, H.L, Agrawal, R, Gutmann, T, Delaine, C, Zhang, Y, Artik, G.O, Merriman, A, Eckert, D, Lawrence, M.C, Coskun, U, Fisher, S.J, Forbes, B.E, Safavi-Hemami, H, Hill, C.P, Chou, D.H.C. | | 登録日 | 2021-05-06 | | 公開日 | 2022-03-16 | | 最終更新日 | 2023-03-29 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Symmetric and asymmetric receptor conformation continuum induced by a new insulin.
Nat.Chem.Biol., 18, 2022
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