3QG5
 
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3QF7
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7PPJ
 | | human SLFN5 | | 分子名称: | Schlafen family member 5, ZINC ION | | 著者 | Lammens, K, Metzner, F.J. | | 登録日 | 2021-09-14 | | 公開日 | 2022-01-26 | | 最終更新日 | 2022-02-02 | | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | | 主引用文献 | Structural and biochemical characterization of human Schlafen 5.
Nucleic Acids Res., 50, 2022
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7ZQY
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4W9M
 | | AMPPNP bound Rad50 in complex with dsDNA | | 分子名称: | DNA (5'-D(*GP*GP*TP*CP*GP*GP*TP*CP*AP*CP*CP*GP*AP*CP*C)-3'), DNA (5'-D(*GP*GP*TP*CP*GP*GP*TP*GP*AP*CP*CP*GP*AP*CP*C)-3'), Exonuclease, ... | | 著者 | Rojowska, A, Lammens, K. | | 登録日 | 2014-08-27 | | 公開日 | 2015-01-14 | | 最終更新日 | 2018-10-24 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structure of the Rad50 DNA double-strand break repair protein in complex with DNA.
Embo J., 33, 2014
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2QFD
 | | Crystal structure of the regulatory domain of human RIG-I with bound Hg | | 分子名称: | MERCURY (II) ION, Probable ATP-dependent RNA helicase DDX58 | | 著者 | Cui, S, Lammens, A, Lammens, K, Hopfner, K.P. | | 登録日 | 2007-06-27 | | 公開日 | 2008-02-12 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I.
Mol.Cell, 29, 2008
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2QFB
 | | Crystal structure of the regulatory domain of human RIG-I with bound Zn | | 分子名称: | Probable ATP-dependent RNA helicase DDX58, ZINC ION | | 著者 | Cui, S, Lammens, A, Lammens, K, Hopfner, K.P. | | 登録日 | 2007-06-27 | | 公開日 | 2008-02-12 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The C-Terminal Regulatory Domain Is the RNA 5'-Triphosphate Sensor of RIG-I.
Mol.Cell, 29, 2008
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2W4R
 | | Crystal structure of the regulatory domain of human LGP2 | | 分子名称: | MERCURY (II) ION, PROBABLE ATP-DEPENDENT RNA HELICASE DHX58, SULFATE ION | | 著者 | Pippig, D.A, Hellmuth, J.C, Cui, S, Kirchhofer, A, Lammens, K, Lammens, A, Schmidt, A, Rothenfusser, S, Hopfner, K.P. | | 登録日 | 2008-12-01 | | 公開日 | 2009-02-24 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The Regulatory Domain of the Rig-I Family ATPase Lgp2 Senses Double-Stranded RNA.
Nucleic Acids Res., 37, 2009
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7Q3Z
 | | DNA/RNA binding protein | | 分子名称: | SODIUM ION, Schlafen family member 5, ZINC ION | | 著者 | Huber, E, Lammens, K. | | 登録日 | 2021-10-29 | | 公開日 | 2022-01-26 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural and biochemical characterization of human Schlafen 5.
Nucleic Acids Res., 50, 2022
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7A08
 | | CryoEM Structure of cGAS Nucleosome complex | | 分子名称: | Cyclic GMP-AMP synthase, Histone H2A type 1-C, Histone H2B type 1-C/E/F/G/I, ... | | 著者 | Michalski, S, de Oliveira Mann, C.C, Witte, G, Bartho, J, Lammens, K, Hopfner, K.P. | | 登録日 | 2020-08-07 | | 公開日 | 2020-09-23 | | 最終更新日 | 2021-02-10 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Structural basis for sequestration and autoinhibition of cGAS by chromatin.
Nature, 587, 2020
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4YKE
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7NI5
 | | Human ATM kinase with bound inhibitor KU-55933 | | 分子名称: | 2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one, Serine-protein kinase ATM, ZINC ION | | 著者 | Bartho, J.D, Stakyte, K, Rotheneder, M, Lammens, K, Hopfner, K.P. | | 登録日 | 2021-02-11 | | 公開日 | 2021-09-01 | | 最終更新日 | 2021-10-20 | | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | | 主引用文献 | Molecular basis of human ATM kinase inhibition.
Nat.Struct.Mol.Biol., 28, 2021
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7NI6
 | | Human ATM kinase with bound ATPyS | | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine-protein kinase ATM, ... | | 著者 | Stakyte, K, Rotheneder, M, Lammens, K, Bartho, J.D. | | 登録日 | 2021-02-11 | | 公開日 | 2021-09-01 | | 最終更新日 | 2021-10-20 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Molecular basis of human ATM kinase inhibition.
Nat.Struct.Mol.Biol., 28, 2021
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5DA9
 | | ATP-gamma-S bound Rad50 from Chaetomium thermophilum in complex with the Rad50-binding domain of Mre11 | | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Putative double-strand break protein, ... | | 著者 | Seifert, F.U, Lammens, K, Stoehr, G, Kessler, B, Hopfner, K.-P. | | 登録日 | 2015-08-19 | | 公開日 | 2016-03-02 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50.
Embo J., 35, 2016
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5DAC
 | | ATP-gamma-S bound Rad50 from Chaetomium thermophilum in complex with DNA | | 分子名称: | 4-(2-AMINOETHYL)BENZENESULFONYL FLUORIDE, DNA (5'-D(P*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3'), DNA (5'-D(P*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*GP*G)-3'), ... | | 著者 | Seifert, F.U, Lammens, K, Stoehr, G, Kessler, B, Hopfner, K.-P. | | 登録日 | 2015-08-19 | | 公開日 | 2016-03-02 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.503 Å) | | 主引用文献 | Structural mechanism of ATP-dependent DNA binding and DNA end bridging by eukaryotic Rad50.
Embo J., 35, 2016
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2R8J
 | | Structure of the Eukaryotic DNA Polymerase eta in complex with 1,2-d(GpG)-cisplatin containing DNA | | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, Cisplatin, ... | | 著者 | Carell, T, Alt, A, Lammens, K. | | 登録日 | 2007-09-11 | | 公開日 | 2007-12-11 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta
Science, 318, 2007
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2R8K
 | | Structure of the Eukaryotic DNA Polymerase eta in complex with 1,2-d(GpG)-cisplatin containing DNA | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, 5'-D(*DGP*DTP*DGP*DGP*DTP*DGP*DAP*DGP*DC)-3', 5'-D(P*DGP*DGP*DCP*DTP*DCP*DAP*DCP*DCP*DAP*DC)-3', ... | | 著者 | Carell, T, Alt, A, Lammens, K. | | 登録日 | 2007-09-11 | | 公開日 | 2007-12-11 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Bypass of DNA lesions generated during anticancer treatment with cisplatin by DNA polymerase eta
Science, 318, 2007
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4FCX
 | | S.pombe Mre11 apoenzym | | 分子名称: | DNA repair protein rad32, MANGANESE (II) ION | | 著者 | Schiller, C.B, Lammens, K, Hopfner, K.P. | | 登録日 | 2012-05-25 | | 公開日 | 2012-06-20 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
Nat.Struct.Mol.Biol., 19, 2012
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4FBW
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4FBK
 | | Crystal structure of a covalently fused Nbs1-Mre11 complex with one manganese ion per active site | | 分子名称: | DNA repair and telomere maintenance protein nbs1,DNA repair protein rad32 CHIMERIC PROTEIN, MANGANESE (II) ION, SULFATE ION | | 著者 | Schiller, C.B, Lammens, K, Hopfner, K.P. | | 登録日 | 2012-05-23 | | 公開日 | 2012-06-20 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.379 Å) | | 主引用文献 | Structure of Mre11-Nbs1 complex yields insights into ataxia-telangiectasia-like disease mutations and DNA damage signaling.
Nat.Struct.Mol.Biol., 19, 2012
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4FBQ
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2XGP
 | | Yeast DNA polymerase eta in complex with C8-2-acetylaminofluorene containing DNA | | 分子名称: | 5'-D(*CP*8FG*CP*TP*CP*AP*TP*CP*CP*AP*C)-3', 5'-D(*GP*TP*GP*GP*AP*TP*GP*AP*G)-3', CALCIUM ION, ... | | 著者 | Scheider, S, Lammens, K, Schorr, S, Hopfner, K.P, Carell, T. | | 登録日 | 2010-06-07 | | 公開日 | 2010-11-03 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Mechanism of Replication Blocking and Bypass of Y-Family Polymerase Eta by Bulky Acetylaminofluorene DNA Adducts.
Proc.Natl.Acad.Sci.USA, 107, 2010
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6GPG
 | | Structure of the RIG-I Singleton-Merten syndrome variant C268F | | 分子名称: | MAGNESIUM ION, Probable ATP-dependent RNA helicase DDX58, RNA (5'-R(*CP*GP*AP*CP*GP*CP*UP*AP*GP*CP*GP*UP*CP*G)-3'), ... | | 著者 | Laessig, C, Lammens, K, Hopfer, K.-P. | | 登録日 | 2018-06-05 | | 公開日 | 2018-08-08 | | 実験手法 | X-RAY DIFFRACTION (2.894 Å) | | 主引用文献 | Unified mechanisms for self-RNA recognition by RIG-I Singleton-Merten syndrome variants.
Elife, 7, 2018
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6GK2
 | | Helical reconstruction of BCL10 CARD and MALT1 DEATH DOMAIN complex | | 分子名称: | B-cell lymphoma/leukemia 10, Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | | 著者 | Schlauderer, F, Desfosses, A, Gutsche, I, Hopfner, K.P, Lammens, K. | | 登録日 | 2018-05-18 | | 公開日 | 2018-10-31 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Molecular architecture and regulation of BCL10-MALT1 filaments.
Nat Commun, 9, 2018
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6SKY
 | | FAT and kinase domain of CtTel1 | | 分子名称: | MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1 | | 著者 | Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P. | | 登録日 | 2019-08-16 | | 公開日 | 2019-10-30 | | 最終更新日 | 2020-01-15 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State.
Structure, 28, 2020
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