2P8L
 
 | | Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELLELDKWASLWN | | 分子名称: | gp41 peptide, nmAb 2F5, heavy chain, ... | | 著者 | Julien, J.P, Bryson, S, Pai, E.F. | | 登録日 | 2007-03-22 | | 公開日 | 2007-05-15 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | | 主引用文献 | Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.
J.Mol.Biol., 384, 2008
|
|
2P8M
 | | Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide ELLELDKWASLWN in new crystal form | | 分子名称: | gp41 peptide, nmAb 2F5, heavy chain, ... | | 著者 | Julien, J.P, Bryson, S, Pai, E.F. | | 登録日 | 2007-03-22 | | 公開日 | 2007-05-15 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.
J.Mol.Biol., 384, 2008
|
|
5IDL
 | | Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT8 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT8 | | 著者 | Julien, J.P, Ereno-Orbea, J, Jardine, J.G, Schief, W.R, Wilson, I.A. | | 登録日 | 2016-02-24 | | 公開日 | 2016-10-05 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | HIV-1 broadly neutralizing antibody precursor B cells revealed by germline-targeting immunogen.
Science, 351, 2016
|
|
3D0L
 | | Crystal structure of the HIV-1 broadly neutralizing antibody 2F5 in complex with the gp41 FP-MPER Hyb3K construct 514GIGALFLGFLGAAGS528KK-Ahx-655KNEQELLELDKWASLWN671 | | 分子名称: | 2F5 heavy chain, 2F5 light chain, GLYCEROL, ... | | 著者 | Bryson, S, Julien, J.P, Pai, E.F. | | 登録日 | 2008-05-01 | | 公開日 | 2008-10-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.
J.Mol.Biol., 384, 2008
|
|
3D0V
 | | Crystal structure of the HIV-1 Cross Neutralizing Monoclonal Antibody 2F5 in complex with gp41 Peptide LLELDKWASLW | | 分子名称: | 2F5 Fab heavy chain, 2F5 Fab light chain, gp41 peptide LLELDKWASLW | | 著者 | Bryson, S, Julien, J.P, Pai, E.F. | | 登録日 | 2008-05-02 | | 公開日 | 2008-07-29 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.
J.Mol.Biol., 384, 2008
|
|
3DRQ
 | | Crystal structure of the HIV-1 broadly neutralizing antibody 2F5 in complex with the gp41 FP-MPER Hyb3K construct 514GIGALFLGFLGAAGS528KK-Ahx-655KNEQELLELDKWASLWN671 soaked in PEG/2-propanol solution | | 分子名称: | 2F5 Fab' heavy chain, 2F5 Fab' light chain, GLYCEROL, ... | | 著者 | Bryson, S, Julien, J.P, Pai, E.F. | | 登録日 | 2008-07-11 | | 公開日 | 2008-10-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site.
J.Mol.Biol., 384, 2008
|
|
5VKM
 | | Crystal structure of human CD22 Ig domains 1-3 in complex with alpha 2-6 sialyllactose | | 分子名称: | B-cell receptor CD22, GLYCEROL, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose, ... | | 著者 | Julien, J.P, Ereno-Orbea, J, Sicard, T. | | 登録日 | 2017-04-21 | | 公開日 | 2017-10-04 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Molecular basis of human CD22 function and therapeutic targeting.
Nat Commun, 8, 2017
|
|
5VKJ
 | | Crystal structure of human CD22 Ig domains 1-3 | | 分子名称: | B-cell receptor CD22, GLYCEROL, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Julien, J.P, Ereno-Orbea, J, Sicard, T. | | 登録日 | 2017-04-21 | | 公開日 | 2017-10-04 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.12 Å) | | 主引用文献 | Molecular basis of human CD22 function and therapeutic targeting.
Nat Commun, 8, 2017
|
|
3IDG
 | |
7K9Z
 | | Crystal structure of SARS-CoV-2 receptor binding domain in complex with the Fab fragments of neutralizing antibodies 298 and 52 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 298 Fab Heavy Chain, 298 Fab Light Chain, ... | | 著者 | Newton, J.C, Kucharska, I, Rujas, E, Cui, H, Julien, J.P. | | 登録日 | 2020-09-29 | | 公開日 | 2020-10-28 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Multivalency transforms SARS-CoV-2 antibodies into ultrapotent neutralizers.
Nat Commun, 12, 2021
|
|
7JOO
 | | Crystal structure of ICOS in complex with antibody STIM003 and anti-kappa VHH domain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Inducible T-cell costimulator, ... | | 著者 | Rujas, E, Sicard, T, Julien, J.P. | | 登録日 | 2020-08-06 | | 公開日 | 2020-10-14 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies.
Nat Commun, 11, 2020
|
|
3RFN
 | | Epitope backbone grafting by computational design for improved presentation of linear epitopes on scaffold proteins | | 分子名称: | BB_1wnu_001, ZINC ION | | 著者 | Azoitei, M.L, Ban, Y.A, Julien, J.P, Bryson, S, Schroeter, A, Kalyuzhniy, O, Porter, J.R, Adachi, Y, Baker, D, Szabo, E, Pai, E.F, Schief, W.R. | | 登録日 | 2011-04-06 | | 公開日 | 2011-11-09 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Computational design of high-affinity epitope scaffolds by backbone grafting of a linear epitope.
J.Mol.Biol., 415, 2012
|
|
7UYL
 | | 850 Fab | | 分子名称: | 850 Fab Heavy Chain, 850 Fab Light Chain, GLYCEROL, ... | | 著者 | Kucharska, I, Prieto, K, Julien, J.P. | | 登録日 | 2022-05-06 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire.
Plos Pathog., 18, 2022
|
|
7V05
 | | Complex of Plasmodium falciparum circumsporozoite protein with 850 Fab | | 分子名称: | 850 Fab Heavy Chain, 850 Fab Light Chain, Circumsporozoite protein | | 著者 | Kucharska, I, Prieto, K, Rubinstein, J.L, Julien, J.P. | | 登録日 | 2022-05-09 | | 公開日 | 2022-11-23 | | 最終更新日 | 2022-12-14 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire.
Plos Pathog., 18, 2022
|
|
7UYM
 | | 850 Fab in complex with NANPNANPNANP peptide | | 分子名称: | 850 Fab Heavy Chain, 850 Fab Light Chain, Circumsporozoite protein, ... | | 著者 | Kucharska, I, Prieto, K, Julien, J.P. | | 登録日 | 2022-05-06 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | High-density binding to Plasmodium falciparum circumsporozoite protein repeats by inhibitory antibody elicited in mouse with human immunoglobulin repertoire.
Plos Pathog., 18, 2022
|
|
7UVQ
 | | Pfs230 domain 1 bound by RUPA-97 and 15C5 Fabs | | 分子名称: | Fab Heavy Chain, Fab Kappa Light Chain, Gametocyte surface protein P230 | | 著者 | Ivanochko, D, Julien, J.P. | | 登録日 | 2022-05-02 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.29 Å) | | 主引用文献 | Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230.
Immunity, 56, 2023
|
|
7UVO
 | | Pfs230 domain 1 bound by RUPA-38 Fab | | 分子名称: | CHLORIDE ION, Gametocyte surface protein P230, ISOPROPYL ALCOHOL, ... | | 著者 | Ivanochko, D, Newton, J, Julien, J.P. | | 登録日 | 2022-05-02 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230.
Immunity, 56, 2023
|
|
7UVI
 | | Pfs230 domain 1 bound by RUPA-55 Fab | | 分子名称: | Gametocyte surface protein P230, RUPA-55 Fab heavy chain, RUPA-55 Fab light chain | | 著者 | Ivanochko, D, Newton, J, Julien, J.P. | | 登録日 | 2022-05-02 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.92 Å) | | 主引用文献 | Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230.
Immunity, 56, 2023
|
|
7UVH
 | | Pfs230 domain 1 bound by RUPA-32 Fab | | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, AMMONIUM ION, ... | | 著者 | Ivanochko, D, Newton, J, Julien, J.P. | | 登録日 | 2022-05-02 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230.
Immunity, 56, 2023
|
|
7UXL
 | | Crystal structure of malaria transmission-blocking antigen Pfs48/45-6C variant in complex with human antibodies RUPA-44 and RUPA-29 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Gametocyte surface protein P45/48, RUPA-29 Fab Heavy chain, ... | | 著者 | Hailemariam, S, Ivanochko, D, Julien, J.P. | | 登録日 | 2022-05-05 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | | 主引用文献 | Highly potent, naturally acquired human monoclonal antibodies against Pfs48/45 block Plasmodium falciparum transmission to mosquitoes.
Immunity, 56, 2023
|
|
7UVS
 | | Pfs230 domain 1 bound by LMIV230-02 Fab | | 分子名称: | Gametocyte surface protein P230, LMIV230-02 Fab heavy chain, LMIV230-02 Fab light chain, ... | | 著者 | Ivanochko, D, Julien, J.P. | | 登録日 | 2022-05-02 | | 公開日 | 2023-02-15 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230.
Immunity, 56, 2023
|
|
5BK3
 | | Crystal structure of the neutralizing anti-circumsporozoite protein 580 antibody | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 580 Antibody, heavy chain, ... | | 著者 | Scally, S.W, Bosch, A, Triller, G, Wardemann, H, Julien, J.P. | | 登録日 | 2017-09-12 | | 公開日 | 2017-12-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.
Immunity, 47, 2017
|
|
5BK5
 | | Crystal structure of the anti-circumsporozoite protein 663 germline antibody | | 分子名称: | 663 germline antibody, heavy chain, light chain, ... | | 著者 | Scally, S.W, Bosch, A, Triller, G, Wardemann, H, Julien, J.P. | | 登録日 | 2017-09-12 | | 公開日 | 2017-12-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.
Immunity, 47, 2017
|
|
5BK0
 | | Crystal structure of 663 Fab bound to circumsporozoite protein NANP 5-mer | | 分子名称: | 663 Antibody, heavy chain, light chain, ... | | 著者 | Scally, S.W, Bosch, A, Triller, G, Wardemann, H, Julien, J.P. | | 登録日 | 2017-09-12 | | 公開日 | 2017-12-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.
Immunity, 47, 2017
|
|
8DNN
 | | Crystal structure of neutralizing antibody 80 in complex with SARS-CoV-2 receptor binding domain | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 80 FAB HEAVY CHAIN, 80 FAB LIGHT CHAIN, ... | | 著者 | Muthuraman, K, Kucharska, I, Ivanochko, D, Julien, J.P. | | 登録日 | 2022-07-11 | | 公開日 | 2023-05-24 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | | 主引用文献 | A multi-specific, multi-affinity antibody platform neutralizes sarbecoviruses and confers protection against SARS-CoV-2 in vivo.
Sci Transl Med, 15, 2023
|
|
