7UVI

Pfs230 domain 1 bound by RUPA-55 Fab

Summary for 7UVI

• Entry DOI: 10.2210/pdb7uvi/pdb
• Related: 7UVH
• Descriptor: RUPA-55 Fab heavy chain, RUPA-55 Fab light chain, Gametocyte surface protein P230 (3 entities in total)
• Functional Keywords: antibody-fragment, malaria transmission, cell invasion, cell invasion-immune system complex, cell invasion/immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 140381.49

Authors

Ivanochko, D.,Newton, J.,Julien, J.P. (deposition date: 2022-05-02, release date: 2023-02-15, Last modification date: 2023-10-25)

• Primary citation: Ivanochko, D.,Fabra-Garcia, A.,Teelen, K.,van de Vegte-Bolmer, M.,van Gemert, G.J.,Newton, J.,Semesi, A.,de Bruijni, M.,Bolscher, J.,Ramjith, J.,Szabat, M.,Vogt, S.,Kraft, L.,Duncan, S.,Lee, S.M.,Kamya, M.R.,Feeney, M.E.,Jagannathan, P.,Greenhouse, B.,Sauerwein, R.W.,Richter King, C.,MacGill, R.S.,Bousema, T.,Jore, M.M.,Julien, J.P.; Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230.; Immunity, 56:420-432.e7, 2023; PubMed: 36792575; DOI: 10.1016/j.immuni.2023.01.013

Experimental method

X-RAY DIFFRACTION (2.92 Å)