7JOO
Crystal structure of ICOS in complex with antibody STIM003 and anti-kappa VHH domain
Summary for 7JOO
| Entry DOI | 10.2210/pdb7joo/pdb |
| Descriptor | anti-kappa VHH, STIM003 Fab Heavy chain, STIM003 Fab Light chain, ... (7 entities in total) |
| Functional Keywords | immune checkpoint, immune system, glycoprotein, receptor, t-cell, antibody |
| Biological source | Lama glama More |
| Total number of polymer chains | 4 |
| Total formula weight | 73854.03 |
| Authors | Rujas, E.,Sicard, T.,Julien, J.P. (deposition date: 2020-08-06, release date: 2020-10-14, Last modification date: 2023-10-25) |
| Primary citation | Rujas, E.,Cui, H.,Sicard, T.,Semesi, A.,Julien, J.P. Structural characterization of the ICOS/ICOS-L immune complex reveals high molecular mimicry by therapeutic antibodies. Nat Commun, 11:5066-5066, 2020 Cited by PubMed: 33033255DOI: 10.1038/s41467-020-18828-4 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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