7JOO
Crystal structure of ICOS in complex with antibody STIM003 and anti-kappa VHH domain
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (K) | anti-kappa VHH | polymer | 121 | 11326.3 | 1 | Lama glama | ||
| 2 | B (H) | STIM003 Fab Heavy chain | polymer | 227 | 24164.9 | 1 | Homo sapiens | ||
| 3 | C (L) | STIM003 Fab Light chain | polymer | 215 | 23619.2 | 1 | Homo sapiens | ||
| 4 | D (C) | Inducible T-cell costimulator | polymer | 128 | 14430.3 | 1 | UniProt (Q9Y6W8) Pfam (PF15910) | Homo sapiens (human) | Activation-inducible lymphocyte immunomediatory molecule |
| 5 | E (H) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | F (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 7 | G, H, I, J (K, H, L, C) | water | water | 18.0 | 166 | Chemie (HOH) |
Sequence modifications
C: 19 - 138 (UniProt: Q9Y6W8)
| PDB | External Database | Details |
|---|---|---|
| Gln 23 | Asn 23 | conflict |
| Ala 136 | Cys 136 | conflict |
| Ala 137 | Cys 137 | conflict |
| Gly 139 | - | expression tag |
| Thr 140 | - | expression tag |
| Glu 141 | - | expression tag |
| Asn 142 | - | expression tag |
| Leu 143 | - | expression tag |
| Tyr 144 | - | expression tag |
| Phe 145 | - | expression tag |
| Gln 146 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 73540.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 313.3 | |
| All* | Total formula weight | 73854.0 |
