3DRQ

Crystal structure of the HIV-1 broadly neutralizing antibody 2F5 in complex with the gp41 FP-MPER Hyb3K construct 514GIGALFLGFLGAAGS528KK-Ahx-655KNEQELLELDKWASLWN671 soaked in PEG/2-propanol solution

Summary for 3DRQ

Entry DOI	10.2210/pdb3drq/pdb
Related	2P8M 3D0L 3DRO 3DRT 3DRV
Descriptor	2F5 Fab' light chain, 2F5 Fab' heavy chain, gp41 peptide epitope, ... (5 entities in total)
Functional Keywords	hiv-1, 2f5, gp41, nmab, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	52263.78
Authors	Bryson, S.,Julien, J.P.,Pai, E.F. (deposition date: 2008-07-11, release date: 2008-10-07, Last modification date: 2023-11-15)
Primary citation	Julien, J.P.,Bryson, S.,Nieva, J.L.,Pai, E.F. Structural details of HIV-1 recognition by the broadly neutralizing monoclonal antibody 2F5: epitope conformation, antigen-recognition loop mobility, and anion-binding site. J.Mol.Biol., 384:377-392, 2008 Cited by PubMed: 18824005 DOI: 10.1016/j.jmb.2008.09.024 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation