5VKM

Crystal structure of human CD22 Ig domains 1-3 in complex with alpha 2-6 sialyllactose

Summary for 5VKM

Entry DOI	10.2210/pdb5vkm/pdb
Related	5VKJ 5VKK 5VL3
EMDB information	8704 8705
Descriptor	B-cell receptor CD22, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose, ... (5 entities in total)
Functional Keywords	siglec, sialic acid, carbohydrate binding protein, immune system
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	38134.62
Authors	Julien, J.P.,Ereno-Orbea, J.,Sicard, T. (deposition date: 2017-04-21, release date: 2017-10-04, Last modification date: 2023-10-04)
Primary citation	Ereno-Orbea, J.,Sicard, T.,Cui, H.,Mazhab-Jafari, M.T.,Benlekbir, S.,Guarne, A.,Rubinstein, J.L.,Julien, J.P. Molecular basis of human CD22 function and therapeutic targeting. Nat Commun, 8:764-764, 2017 Cited by PubMed: 28970495 DOI: 10.1038/s41467-017-00836-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation